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Desloratadine

Product ID D1774
Cas No. 100643-71-8
Purity ≥97%
Product Unit SizeCostQuantityStock
100 mg $98.00 In stock
500 mg $275.00 In stock
1 g $450.00 In stock
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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
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Description

Desloratadine is a non-sedating tricyclic antihistamine that inhibits H1 histamine receptors. Desloratidine is an active metabolite of loratadine that exhibits anti-allergic, anti-asthma, and anti-inflammatory activities. Desloratadine inhibits histamine-induced bronchoconstriction and is clinically used to treat allergic rhinitis and chronic idiopathic urticaria. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.

100643-71-8

Purity

≥97%

Formula

C19H19ClN2

Formula Wt.

310.82

Chemical Name

8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine

IUPAC Name

8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2, 4-b]pyridine

Synonym

Clarinex

Melting Point

150-151°C

Solubility

Soluble in methanol and ethanol.

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D1774 MSDS PDF

Info Sheet

D1774 Info Sheet PDF

References

Doetkotte R, Opitz K, Kiianmaa K, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. PMID: 16209867.

Glass DJ, Harper AS. Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine. BMC Fam Pract. 2003 Aug 13;4:10. PMID: 12917016.

Walsh GM. Second-generation antihistamines in asthma therapy: is there a protective effect? Am J Respir Med. 2002;1(1):27-34. PMID: 14720073.

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