• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Axitinib

Axitinib

Product ID A9435
Cas No. 319460-85-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $52.50 In stock
25 mg $112.60 In stock
100 mg $188.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Axitinib is an inhibitor of VEGFR that exhibits anticancer chemotherapeutic and anti-angiogenic activities. Axitinib is currently in clinical trials as a potential treatment for renal cell carcinoma. In vitro, axitinib increases levels of CD8+ T cells and decreases levels of myeloid-derived suppressor cells, inhibiting proliferation and increasing apoptosis. In vivo, this compound inhibits expression of iNOS, arginase, IL-6, TNF-α, and IFN-γ, increasing apoptosis and inhibiting tumor growth. In animal models of lung adenocarcinoma, axitinib decreases tumor vasculature and lesion growth.

Product Info

Cas No.

319460-85-0

Purity

≥98%

Formula

C22H18N4OS

Formula Wt.

386.47

Chemical Name

N-methyl-2-[[3-[(1E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl]sulfanyl]benzamide

IUPAC Name

N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl] benzamide

Melting Point

213-224°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A9435 MSDS PDF

Info Sheet

A9435 Info Sheet PDF

References

Zhang X, Fang X, Gao Z, et al. Axitinib, a selective inhibitor of vascular endothelial growth factor receptor, exerts an anticancer effect in melanoma through promoting antitumor immunity. Anticancer Drugs. 2014 Feb;25(2):204-11. PMID: 24135499.

Gross-Goupil M, François L, Quivy A, et al. Axitinib: A Review of its Safety and Efficacy in the Treatment of Adults with Advanced Renal Cell Carcinoma. Clin Med Insights Oncol. 2013 Oct 29;7:269-277. PMID: 24250243.

Majeti BK, Lee JH, Simmons BH, et al. VEGF is an important mediator of tumor angiogenesis in malignant lesions in a genetically engineered mouse model of lung adenocarcinoma. BMC Cancer. 2013 Apr 29;13(1):213. [Epub ahead of print]. PMID: 23627488.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A0962

    Adrenocorticotropic Hormone (1-4)

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • B5074

    BMS-599626

    EGFR, VEGFR inhibitor.

    ≥98%
  • J0001

    J-147

    Phenyl hydrazide; neuronal oxidative stress inh...

    ≥98%
  • S0134

    Saikosaponin D

    Triterpene saponin found in Bupleurum.

    ≥98%
  • P7021

    Prednisone Acetate

    Synthetic prednisolone prodrug; glucocorticoid ...

    ≥98%
  • D5746

    Dolasetron

    5-HT3 antagonist.

    ≥98%
  • G1308

    GDC-0032

    PI3K inhibitor.

    ≥98%
  • C3262

    Ciprofloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • A5056

    Amorolfine Hydrochloride

    14α-demethylase inhibitor.

    ≥98.5%
  • R2788

    RGW-611

    Morpholine derivative.

    ≥98%
  • A8070

    Auraptene

    Monoterpene coumarin ether found in Citrus; PPA...

    ≥98%
  • M0272

    Mastoparan 7

    Antimicrobial peptide found in bee and wasp ven...

    ≥95%
  • D3330

    Dihydrotanshinone

    Found in Salvia; fatty acid synthase and AChE i...

    ≥90%
  • B1769

    Bergenin

    Trihydroxybenzoic acid glycoside found in Berge...

    ≥98%
  • M1873

    S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine

    Sulforaphane-cysteine conjugate.

    ≥98%
  • A5202

    Anabasine Hydrochloride

    Alkaloid originally found in species of Nicotia...

    ≥98%
  • N7604

    Naltriben

    δ2OR antagonist.

    ≥95%
  • D3223

    Difloxacin Hydrochloride

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • A4441

    Allicin, aqueous solution

    Organosulfur found in garlic; Kir K+ channel ac...

    ≥98%
  • A0964

    Adrenocorticotropic Hormone (1-13), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only