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Mitiglinide Calcium

Product ID M3577
Cas No. 145375-43-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $138.50 In stock
250 mg $254.80 In stock
1 g $812.30 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Mitiglinide is an anti-diabetic/anti-hyperglycemic compound that increases insulin secretion and decreases plasma glucose in pancreatic β cells. The short action of mitiglinide mimics the in vivo duration and timing of insulin release. Mitiglinide decreases levels of FGF-21, altering glucose metabolism. Mitiglinide directly inhibits ATP-sensitive K+ channels and may also activate ryanodine (RyR) receptors, altering intracellular Ca2+ release.

Product Info

Cas No.

145375-43-5

Purity

≥98%

Formula

2(C19H24NO3)Ca

Formula Wt.

668.88

IUPAC Name

4-(1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl)-2-benzyl-4-oxobutanoic acid InChI: InChI=1S/C19H25NO3/c21-18(20-12-15-8-4-5-9-16(15)13-20)11-17(19(22)23) 10-14-6-2-1-3-7-14/h1-3,6-7,15-17H,4-5,8-13H2,(H,22,23)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M3577 MSDS PDF

Info Sheet

M3577 Info Sheet PDF

References

Phillippe HM, Wargo KA. Mitiglinide for type 2 diabetes treatment. Expert Opin Pharmacother. 2013 Oct;14(15):2133-44. PMID: 23992284.

Wang B, Yang G, Yang M, et al. Mitiglinide treatment may decreases plasma fibroblast growth factor-21 levels in individuals with new-onset T2DM. Cytokine. 2012 Feb;57(2):300-3. PMID: 22129626.

Phillippe HM, Wargo KA. Mitiglinide: a novel agent for the treatment of type 2 diabetes mellitus. Ann Pharmacother. 2010 Oct;44(10):1615-23. PMID: 20841518.

Shigeto M, Katsura M, Matsuda M, et al. Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum. J Pharmacol Exp Ther. 2007 Jul;322(1):1-7. PMID: 17409272.

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