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D,L-Homocysteine Thiolactone Hydrochloride

Product ID H5748
Cas No. 6038-19-3
Purity ≥98%
Product Unit SizeCostQuantityStock
50 g $77.90 In stock
100 g $135.30 In stock
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  • Product Info
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  • Description
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Description

D,L-Homocysteine thiolactone binds to and induces conformational changes in various plasma proteins. This compound slows coagulation and causes more tightly packed fibrin structure formation; it is detrimental to vascular function and may induce oxidative stress. D,L-Homocysteine thiolactone exhibits cardiomodulatory, epileptogenic, and neurotoxic activities. In isolated hearts, this compound decreases left ventricular systolic blood pressure and cardiac force. In vivo, this compound induces seizures and is thought to play a role in the development of Alzheimer’s disease.

Product Info

Cas No.

6038-19-3

Purity

≥98%

Formula

C4H7NOS • HCl

Formula Wt.

153.63

IUPAC Name

3-aminothiolan-2-one;hydrochloride

Synonym

(+-)-Dihydro-3-amino-2(3H)-thiophenone hydrochloride

Melting Point

201-202°C

Solubility

Soluble in water.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

H5748 MSDS PDF

Info Sheet

H5748 Info Sheet PDF

References

Hrnčić D, Rašić-Marković A, Macut D, et al. Homocysteine thiolactone-induced seizures in adult rats are aggravated by inhibition of inducible nitric oxide synthase. Hum Exp Toxicol. 2014 May;33(5):496-503. PMID: 23760255.

Genoud V, Lauricella AM, Kordich LC, et al. Impact of homocysteine-thiolactone on plasma fibrin networks. J Thromb Thrombolysis. 2014 Mar 23. [Epub ahead of print]. PMID: 24659173.

Zivkovic V, Jakovljevic V, Pechanova O, et al. Effects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart: the role of different gasotransmitters. Biomed Res Int. 2013;2013:318471. PMID: 24350259.

Borowczyk K, Shih DM, Jakubowski H. Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1. J Alzheimers Dis. 2012;30(2):225-31. PMID: 22406444.

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