Description
CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2) that exhibits neuroprotective activity. This compound may decrease neuronal injury in models of neurodegenerative diseases such as Parkinson’s disease.
Product Unit Size | Cost | Quantity | Stock |
---|
CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2) that exhibits neuroprotective activity. This compound may decrease neuronal injury in models of neurodegenerative diseases such as Parkinson’s disease.
Cas No. | 1191911-27-9 |
---|---|
Purity | ≥98% |
Formula | C22H25ClN6O4S |
Formula Wt. | 504.99 |
Chemical Name | N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide |
IUPAC Name | N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide |
Synonym | SCHEMBL1460537; CHEBI:78414; BCP15148 |
Solubility | 100mM in DMSO |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet | |
Brochures |
Kramer T, Lo Monte F, Göring S, et al. Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models. ACS Chem Neurosci. 2012 Mar 21;3(3):151-60. PMID: 22860184.
Ramsden N, Perrin J, Ren Z, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. PMID: 21812418.
Antimicrobial peptide found in amphibians.
mAChR agonist, selective for M2.
Rapamycin impurity
Coccidiostat; dihydrofolate reductase inhibitor...
p110β PI3K inhibitor.
Fluoroquinolone; topoisomerase IV and bacterial...
Endogenous peptide, involved in paracrine and a...
Curcumin derivative.
Trichothecene mycotoxin produced by Fusarium.
FXR agonist.
Endogenous pterin coenzyme required for release...
RIP1 inhibitor.
Akt inhibitor.
Imidazole; 14-α demethylase inhibitor, potenti...
AT1 inhibitor.
Dihydropyridine; L-type and T-type Ca2+ channel...
p53 activator.
Isothiocyanate found in cruciferous vegetables,...
p110α PI3K and mTOR inhibitor.
Fluoroquinolone; topoisomerase IV and bacterial...