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CZC-54252

Product ID C9808
Cas No. 1191911-27-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $88.60 In stock
5 mg $156.60 In stock
25 mg $552.00 In stock
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Description

CZC-54252 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2) that exhibits neuroprotective activity. This compound may decrease neuronal injury in models of neurodegenerative diseases such as Parkinson’s disease.

Product Info

Cas No.

1191911-27-9

Purity

≥98%

Formula

C22H25ClN6O4S

Formula Wt.

504.99

Chemical Name

N-{2-[(5-chloro-2-{[2-methoxy-4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}methanesulfonamide

IUPAC Name

N-{2-[(5-Chloro-2-{[2-methoxy-4-(4-morpholinyl)phenyl]amino}-4-pyrimidinyl)amino]phenyl}methanesulfonamide

Synonym

SCHEMBL1460537; CHEBI:78414; BCP15148

Solubility

100mM in DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C9808 MSDS PDF

Info Sheet

C9808 Info Sheet PDF

Brochures

LRRK2 Flyer

References

Kramer T, Lo Monte F, Göring S, et al. Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models. ACS Chem Neurosci. 2012 Mar 21;3(3):151-60. PMID: 22860184.

Ramsden N, Perrin J, Ren Z, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8. PMID: 21812418.

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