• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Rutaecarpine, synthetic

Rutaecarpine, synthetic

Product ID R8179
Cas No. 84-26-4
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $92.00 In stock
100 mg $191.50 In stock
250 mg $408.50 In stock
1 g $865.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Rutaecarpine is an indoloquinazoline alkaloid originally found in Evodia; it exhibits anti-inflammatory, anti-atherosclerotic, cardioprotective, anorexigenic, and anti-obesity activities. Rutaecarpine inhibits COX-2 and also decreases food intake, weight gain, and serum glucose, leptin, and insulin levels in vivo by inhibiting expression of neuropeptide Y and AgRP. Rutaecarpine also inhibits accumulation of macrophages and cholesterol in atherosclerotic lesions and increases cholesterol excretion in other animal models. Additionally, rutaecarpine inhibits hypoxia-induced production of ROS and lactate dehydrogenase and suppresses apoptosis in myocardiocytes. In other cellular models, rutaecarpine decreases corticosterone production, potentially through inhibition of cAMP, 3β-hydroxysteroid dehydrogenase, and 11β-hydroxylase activity. Rutaecarpine also inhibits production of ROS, NO, and iNOS, potentially through inhibition of NADPH oxidase. In macrophages, rutaecarpine inhibits arachidonic acid release and decreases production of prostaglandin E2 (PGE2); in other in vitro models, it inhibits collagen-stimulated formation of thromboxane B2 and inosine monophosphate.

Product Info

Cas No.

84-26-4

Purity

≥98%

Formula

C18H13N3O

Formula Wt.

287.32

Chemical Name

8,13-Dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazolin- 5(7H)-one

IUPAC Name

3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-1(21),2(10),4,6,8,15,17,19-octaen-14-one

Synonym

Rutecarpine

Melting Point

259.5-260°C

Solubility

Soluble in alcohol, benzene, chloroform and ether. Practically insoluble in water.

Appearance

Grey white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

R8179 MSDS PDF

Info Sheet

R8179 Info Sheet PDF

References

Xu Y, Liu Q, Xu Y, et al. Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through up-regulating ABCA1 and SR-BI within RCT. J Lipid Res. 2014 Jun 7. [Epub ahead of print]. PMID: 24908654.

Chen YC, Zeng XY, He Y, et al. Rutaecarpine analogues reduce lipid accumulation in adipocytes via inhibiting adipogenesis/lipogenesis with AMPK activation and UPR suppression. ACS Chem Biol. 2013 Oct 18;8(10):2301-11. PMID: 23962138.

Bao MH, Dai W, Li YJ, et al. Rutaecarpine prevents hypoxia-reoxygenation-induced myocardial cell apoptosis via inhibition of NADPH oxidases. Can J Physiol Pharmacol. 2011 Mar;89(3):177-86. PMID: 21423291.

Kim SJ, Lee SJ, Lee S, et al. Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropeptides NPY and AgRP in mice. Biochem Biophys Res Commun. 2009 Nov 20;389(3):437-42. PMID: 19732749.

Yu PL, Chao HL, Wang SW, et al. Effects of evodiamine and rutaecarpine on the secretion of corticosterone by zona fasciculata-reticularis cells in male rats. J Cell Biochem. 2009 Oct 1;108(2):469-75. PMID: 19639602.

Sheu JR, Hung WC, Lee YM, et al. Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. Eur J Pharmacol. 1996 Dec 30;318(2-3):469-75. PMID: 9016940.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M0275

    Mastoparan 17

    Peptide, inactive mastoparan analog used to mea...

    ≥95%
  • C1630

    Cefoperazone Sodium

    β-lactam cephalosporin; penicillin binding pro...

    ≥98%
  • H9862

    Hypothemycin

    Polyketide found in Setophoma.

    ≥96%
  • C1718

    Cepharanthine, 95%

    Alkaloid found in Stephania.

    ≥95%
  • M185770

    5-Methyltetrahydrofolic Acid

    Folic acid derivative

    ≥98%
  • P6818

    Prednisolone

    Cortisol derivative; glucocorticoid agonist.

    ≥98%
  • Q8135

    Quinestrol

    Synthetic steroid hormone, estrogen analog, use...

    ≥98%
  • R8076

    Rutin Hydrate

    Flavonoid glycoside found in fruit, asparagus, ...

    ≥95%
  • I0010

    5-(9-Isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine

    Intermediate in the synthesis of purine analogs...

    ≥98%
  • P337538

    (-)-Pinostrobin

    Neuroprotective flavonoid

    ≥99%
  • S6168

    Spirapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • H9611

    Hydrocortisone

    Endogenous steroid hormone involved in stress s...

    ≥98%
  • C086007

    CC-671

    TTK/CLK2 inhibitor.

    ≥98%
  • G3554

    Ginsenoside Rb3

    Triterpene saponin found in species of Panax.

    ≥98%
  • G0104

    Gabexate Mesylate

    Proteasome inhibitor.

    ≥99%
  • I0516

    I-BET151

    BRD2/3/4 inhibitor.

    ≥98%
  • T3097

    Thymosin α-1 Acetate

    Endogenous peptide, involved in hormone regulat...

    ≥95%
  • T1002

    2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

    Synthesis intermediate

    ≥95%
  • B242042

    BGB-283

    Dual RAF/EGFR inhibitor.

    ≥98%
  • V3455

    Vinpocetine

    Targets nuclear factor kappa B activation.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only