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Daunorubicin Hydrochloride

Product ID D0182
Cas No. 23541-50-6
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $88.60 In stock
50 mg $272.50 In stock
100 mg $511.10 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Daunorubicin is an anthracycline first produced by Streptomyces. Daunorubicin exhibits anticancer chemotherapeutic activity and is clinically used to treat various cancers, including neuroblastoma and acute myelogenous leukemia (AML). Like other anthracyclines, daunorubicin acts as an intercalator and inhibitor of topoisomerase II. Daunorubicin also promotes histone H2AX eviction from chromatin, inhibiting DNA repair mechanisms.

Product Info

Cas No.

23541-50-6

Purity

≥98%

Formula

C27H29NO10 • HCl

Formula Wt.

564.0

Chemical Name

(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-α-L- lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11- trihydroxy-1-methoxy-5,12-naphthacenedione

IUPAC Name

(7S,9S)-9-acetyl-7-[(2R,4S,5S, 6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9, 11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5, 12-dione;hydrochloride

Synonym

Daunomycin, Leukaemomycin C, Rubidomycin, RP-13057, Cerubidin.

Melting Point

188-190°C(dec.)

Solubility

Soluble in water or ethanol.

Appearance

Orange-red Crystalline Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D0182 MSDS PDF

Info Sheet

D0182 Info Sheet PDF

References

Pang B, Qiao X, Janssen L, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908. PMID: 23715267.

Quigley GJ, Wang AH, Ughetto G, et al. Molecular structure of an anticancer drug-DNA complex: daunomycin plus d(CpGpTpApCpG). Proc Natl Acad Sci U S A. 1980 Dec;77(12):7204-8. PMID: 6938965.

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