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O6-Benzylguanine

Product ID B1855
Cas No. 19916-73-5
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $70.40 In stock
250 mg $293.10 In stock
1 g $879.20 In stock
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  • Product Info
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

O6-Benzylguanine (O6-BG) is a synthetic derivative of guanine often used to examine DNA repair mechanisms. O6-BG acts as an inhibitor of O6-methylguanine DNA methyltransferase (MGMT), an enzyme that repairs damage to guanine residues in DNA. As many alkylating and cross-linking chemotherapeutics act on guanine residues to induce DNA damage in cancer cells, O6-BG prevents the repair of the damaged DNA, allowing apoptosis and other mechanisms of cell death to occur. In animals and humans, O6-BG shows some benefit in improving efficacy of co-administered treatments, potentially increasing survival time. This compound is currently in clinical trials examining its anticancer chemotherapeutic potential.

Product Info

Cas No.

19916-73-5

Purity

≥98%

Formula

C12H11N5O

Formula Wt.

241.25

IUPAC Name

6-phenylmethoxy-7H-purin-2-amine

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B1855 MSDS PDF

Info Sheet

B1855 Info Sheet PDF

References

Qian L, Zheng J, Wang K, et al. Cationic core-shell nanoparticles with carmustine contained within O6-benzylguanine shell for glioma therapy. Biomaterials. 2013 Nov;34(35):8968-78. PMID: 23953782.

Quinn JA, Jiang SX, Reardon DA, et al. Phase II trial of temozolomide plus O6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. J Clin Oncol. 2009 Mar 10;27(8):1262-7. PMID: 19204199.

Quinn JA, Jiang SX, Carter J, et al. Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme. Clin Cancer Res. 2009 Feb 1;15(3):1064-8. PMID: 19188181.

Friedman HS, Keir S, Pegg AE, et al. O6-benzylguanine-mediated enhancement of chemotherapy. Mol Cancer Ther. 2002 Sep;1(11):943-8. PMID: 12481416.

Friedman HS, Pluda J, Quinn JA, et al. Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J Clin Oncol. 2000 Oct 15;18(20):3522-8. PMID: 11032594.

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