LKT Labs

Biochemicals for Life Science Research

Citrinin

Citrinin

Product ID C3479
Cas No. 518-75-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $70.00 In stock
5 mg $237.00 In stock
10 mg $430.00 In stock
Bulk Quote

Quicklinks

Description

Citrinin is a mycotoxin initially produced by Penicillum, Aspergillus, and Monascus. Citrinin exhibits cytotoxic, cardiotoxic, nephrotoxic, and pro-oxidative activities. In leydig cells, citrinin inhibits testosterone production and induces caspase-mediated apoptosis. In embryos, citrinin alters heart morphology, causing malformations, edema, and red cell accumulation. Additionally, citrinin increases membrane permeability in mitochondria, increasing generation of ROS and superoxide anions.

Product Info

Cas No.

518-75-2
Purity

≥98%
Formula

C13H14O5
Formula Wt.

250.249
IUPAC Name

(3R,4S)-6-hydroxy-3,4,5-trimethyl-8-oxo-3, 4-dihydroisochromene-7-carboxylic acid
Melting Point

175°C (dec.)
Appearance

Yellow Crystals

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C3479 MSDS PDF
Info Sheet

C3479 Info Sheet PDF

References

Wu TS, Yang JJ, Yu FY, et al. Cardiotoxicity of mycotoxin citrinin and involvement of microRNA-138 in zebrafish embryos. Toxicol Sci. 2013 Dec;136(2):402-12. PMID: 24052562.

Liu S, Wang D, Zhang J, et al. Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells. Toxicol In Vitro. 2012 Sep;26(6):856-61. PMID: 22564900.

Flajs D, Peraica M. Toxicological properties of citrinin. Arh Hig Rada Toksikol. 2009 Dec;60(4):457-64. PMID: 20061247.

Da Lozzo EJ, Oliveira MB, Carnieri EG. Citrinin-induced mitochondrial permeability transition. J Biochem Mol Toxicol. 1998;12(5):291-7. PMID: 9664235.

Ribeiro SM, Chagas GM, Campello AP, et al. Mechanism of citrinin-induced dysfunction of mitochondria. V. Effect on the homeostasis of the reactive oxygen species. Cell Biochem Funct. 1997 Sep;15(3):203-9. PMID: 9377799.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B165122

    Bedaquiline

    Bactericidal

    ≥99%
  • G720004

    GS-4997

    ASK1 inhibitor.

    ≥99%
  • A7668

    Atracurium Besylate

    Non-depolarizing NMJ blocker; AChR antagonist.<...

    ≥95%
  • B1603

    Beauvericin

    Cyclic hexadepsipeptide mycotoxin produced by C...

    ≥95%
  • T0115

    Taxol Side Chain Acid

    Side chain commonly attached to taxanes.

    ≥98%
  • A4445

    Allopurinol

    Purine (hypoxanthine) analog; xanthine oxidase ...

    ≥98%
  • A4002

    AK-7

    SIRT2 inhibitor.

    ≥98%
  • A0401

    Abacavir

    Nucleoside (guanosine) analog; RT, guanylyl cyc...

    ≥98%
  • P1634

    Peimine

    Steroidal alkaloid found in Fritillaria; TRPV1 ...

    ≥98%
  • S6247

    Splitomicin

    SIRT1/2 inhibitor.

    ≥98%
  • P0392

    Paxilline

    Neuroactive mycotoxin produced by Penicillum an...

    ≥98%
  • D6108

    1,4-DPCA

    Prolyl hydroxylase inhibitor.

    ≥98%
  • P2512

    S-(N-Phenethylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • R2400

    RG-108

    DNMT inhibitor.

    ≥98%
  • H1658

    Heparin Sodium

    Endogenous glycosaminoglycan that is produced b...

    Bioassay ≥140 U/mg
  • G3462

    Ginsenoside F3

    Triterpene saponin found in species of Panax.

    ≥98%
  • M1746

    Melphalan

    Nitrogen mustard, DNA alkylator.

    ≥95%
  • R0020

    RAF265

    B-Raf, VEGFR2, c-Raf, PDGFR, CSF-1R, RET, c-Kit...

    ≥98%
  • E9418

    Exendin 3 (9-39)

    Peptide, GLP-1 analog found in Heloderma; GLP-1...

    ≥95%
  • T0095

    Baccatin III

    Diterpene found in Taxus, used to synthesize ta...

    ≥98%