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Betulin is a pentacyclic triterpene found in birch bark. This compound can induce apoptosis and inhibit angiogenesis, lending it a wide variety of functions, including anticancer, antiviral, anti-inflammatory, anti-fibrotic, antioxidative, and antibacterial roles. Betulin is hepatoprotective as well, as it suppresses symptoms of ethanol-induced fatty liver by inhibiting acidophilic necrosis; it also prevents liver fibrosis by inhibiting production and migration of ROS.
| Cas No. | 473-98-3 |
|---|---|
| Purity | ≥98% |
| Formula | C30H50O2 |
| Formula Wt. | 442.72 |
| Chemical Name | Lup-20(29)-ene-3β,28-diol |
| IUPAC Name | (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(hydroxymethyl)-5a,5b,8, 8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13, 13a,13b-hexadecahydrocyclopenta[a]chrysen-9-ol |
| Melting Point | 256–257°C |
| Solubility | Soluble in DMF (2.5 mg/mL), DMSO (2 mg/mL), ethanol (5 mg/mL). Slightly soluble in chloroform, methanol. |
| Appearance | White powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Wan Y, Jiang S, Lian LH, et al. Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro. Int Immunopharmacol. 2013 Jun 28;17(2):184-190. [Epub ahead of print] PMID: 23816536.
Jonnalagadda SC, Corsello MA, Sleet CE. Betulin-Betulinic Acid Natural Product Based Analogs as Anti-Cancer Agents. Anticancer Agents Med Chem. 2013 Jun 11. [Epub ahead of print] PubMed PMID: 23848199.
Szuster-Ciesielska A, Plewka K, Kandefer-Szerszeń M. Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells. Pharmacol Rep. 2011;63(5):1109-23. PMID: 22180353.
