• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
20(S)-Ginsenoside Rh2

20(S)-Ginsenoside Rh2

Product ID G3453
Cas No. 78214-33-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $134.30 In stock
5 mg $324.90 In stock
10 mg $554.10 In stock
25 mg $1,107.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ginsenoside Rh2 is a triterpene saponin found in Panax and exhibits anticancer chemotherapeutic, anti-metastatic, neuroprotective, cognition enhancing, anti-inflammatory, anti-osteoporotic, antioxidative, and anti-diabetic activities. Ginsenoside Rh2 inhibits aldose reductase and also decreases levels of ROS in keratinocytes. Ginsenoside Rh2 inhibits cell migration, decreases levels of matrix metalloproteinase 3 (MMP3), and increases recruitment of HDAC4 in liver carcinoma cells. In cellular and animal models of glioblastoma, ginsenoside Rh2 inhibits cell and tumor growth. Additionally, ginsenoside Rh2 improves learning and memory by decreasing levels of amyloid-β (Aβ) in animal models of Alzheimer’s disease. In LPS-stimulated macrophages, this compound decreases the release of IL-1β, TNF-α, IL-6, PGE2, and NO and suppresses phosphorylation of p38 MAPK, ERK1/2, JAK, and NF-κB. Ginsenoside Rh2 inhibits osteoclastogenesis by suppressing RANKL-induced osteoclast differentiation in vitro and in vivo. This compound also induces β-cell proliferation by activating Akt and PDX-1, improves glucose tolerance, and increases insulin levels in animal models.

Product Info

Cas No.

78214-33-2

Purity

≥98%

Formula

C36H62O8 H2O

Formula Wt.

640.89

IUPAC Name

(2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

Synonym

20S-GinsenosideRh2, 20S-protopanaxdiol-3-O-β-D- glucopyranoside, β-D-Glucopyranoside

Solubility

Soluble in ethanol to 10 mM. Insoluble in water.

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G3453 MSDS PDF

Info Sheet

G3453 Info Sheet PDF

References

Fatmawati S, Ersam T, Yu H, et al. 20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng. Bioorg Med Chem Lett. 2014 Aug 12. [Epub ahead of print]. PMID: 25152999.

Shi Q, Li J, Feng Z, et al. Effect of ginsenoside Rh2 on the migratory ability of HepG2 liver carcinoma cells: Recruiting histone deacetylase and inhibiting activator protein 1 transcription factors. Mol Med Rep. 2014 Jul 18. [Epub ahead of print]. PMID: 25051397.

Li S, Gao Y, Ma W, et al. EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2. Tumour Biol. 2014 Jun;35(6):5593-8. PMID: 24557544.

Qiu J, Li W, Feng SH, et al. Ginsenoside Rh2 promotes nonamyloidgenic cleavage of amyloid precursor protein via a cholesterol-dependent pathway. Genet Mol Res. 2014 May 9;13(2):3586-98. PMID: 24854439.

Yi PF, Bi WY, Shen HQ, et al. Inhibitory effects of sulfated 20(S)-ginsenoside Rh2 on the release of pro-inflammatory mediators in LPS-induced RAW 264.7 cells. Eur J Pharmacol. 2013 Jul 15;712(1-3):60-6. PMID: 23665488.

Choi WY, Lim HW, Lim CJ. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6. PMID: 23278699.

He L, Lee J, Jang JH, et al. Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-κB, NFATc1 and c-Fos. Bone. 2012 Jun;50(6):1207-13. PMID: 22484180.

Wang Y, Wang H, Liu Y, et al. Antihyperglycemic effect of ginsenoside Rh2 by inducing islet β-cell regeneration in mice. Horm Metab Res. 2012 Jan;44(1):33-40. PMID: 22205570.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A0921

    N-Acetyl-D-Leucine

    D-amino acid, incorporated into bacterial cell ...

    ≥98%
  • P691320

    PRI-724

    Wnt/beta-catenin/CBP inhibitor

    ≥98%
  • P1753

    Penicillamine

    Penicillin derivative, chelating agent; carboxy...

    ≥97%
  • G3461

    Ginsenoside F2

    Triterpene saponin found in species of Panax.

    ≥98%
  • T162051

    Tebipenem

    Broad-spectrum antibiotic

    ≥99%
  • E537333

    Enniatin A1

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • C0168

    Canthaxanthin

    Carotenoid terpene pigment found in various pla...

    ≥9% (product contains stabilizers)
  • D1749

    Demecolcine

    Used to study embryonic cloning; microtubule po...

    ≥97%
  • T1002

    2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

    Synthesis intermediate

    ≥95%
  • S0400

    SB-431542

    ALK4/5/7 (activin-like) inhibitor, TGF-β inhib...

    ≥98%
  • R3449

    Rimonabant Hydrochloride

    CB1 inverse agonist.

    ≥98%
  • Z161024

    α-Zearalenol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • N9874

    Nystatin

    Polyene macrolide, induces pore formation in fu...

    4400u/mg
  • B3300

    BI-6727

    PLK1 inhibitor.

    ≥99%
  • N5652

    Nonactin

    Naturally-ocurring neurtral cyclic ionophore, m...

    ≥95%, TLC
  • D3362

    Dipyridamole

    PDE and adenosine deaminase inhibitor.

    ≥98%
  • S0278

    Satraplatin

    Pt-based DNA cross-linker.

    ≥98%
  • H9712

    (E)-4-Hydroxytamoxifen

    SERM.

    ≥97%
  • C4800

    CM346 Hydrochloride

    Potential anxiolytic.

    ≥99%
  • T3357

    Tioconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only