Description
Raltegravir is an antiviral compound that inhibits HIV integrase; it is clinically used to treat HIV infection. In pre-clinical models, raltegravir decreases infection rates by preventing insertion of HIV-1 DNA into the host genome.
Product Unit Size | Cost | Quantity | Stock |
---|
Raltegravir is an antiviral compound that inhibits HIV integrase; it is clinically used to treat HIV infection. In pre-clinical models, raltegravir decreases infection rates by preventing insertion of HIV-1 DNA into the host genome.
Cas No. | 518048-05-0 |
---|---|
Purity | ≥99% |
Formula | C20H21FN6O5 |
Formula Wt. | 444.42 |
IUPAC Name | N-(4-Fluorobenzyl)-5-hydroxy-1-methyl-2-(2-{[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino}-2-propanyl)-6-oxo-1,6-dihydro-4-pyrimidinecarboxamide |
Synonym | MK-0518 |
Solubility | soluble in water, slightly soluble in methanol, very slightly soluble in ethanol and acetonitrile and insoluble in isopropanol. The solubility of raltegravir increases with increasing pH such that its solubility in water is approx. 71 mg/mL. Its pKa is 6.3 |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet | |
Brochures |
Taramasso L, Madeddu G, Ricci E, et al. Raltegravir-based therapy in a cohort of HIV/HCV co-infected individuals. Biomed Pharmacother. 2015 Feb;69:233-6. PMID: 25661363.
Mouscadet JF, Tchertanov L. Raltegravir: molecular basis of its mechanism of action. Eur J Med Res. 2009 Nov 24;14 Suppl 3:5-16. PMID: 19959411.
Hicks C, Gulick RM. Raltegravir: the first HIV type 1 integrase inhibitor. Clin Infect Dis. 2009 Apr 1;48(7):931-9. PMID: 19231980.
Triterpene saponin found in Bupleurum.
GLP-1/GIP receptor co-agonist
Statin; HMG-CoA reductase inhibitor.
MET and GSK-3α/β inhibitor.
Non-selective HDAC inhibitor.
Akt inhibitor.
Pyrimidine, glucose analog, used to induce diab...
Microtubule polymerization inhibitor, potential...
Iridoid glycoside found in Gardenia.
Natural steroid hormone produced by arthropods;...
SMAC mimetic; PXR agonist, IAP inhibitor.
Semi-synthetic analog of taxol; microtubule dep...
Benzothiazepine; L-type Ca2+ channel blocker, p...
Peptide; calcineurin inhibitor.
Endogenous peptide hormone, involved in feeding...
Benzisoxazole; 5-HT7 and NMDA agonist, D-amino ...
Nitroimidazole; hypoxic modifier and radiosensi...
Selective CDK2 inhibitor.
Endogenous bile acid; FXR agonist.
Endogenous APP peptide cleavage product, primar...