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Nedaplatin is a second generation platinum compound that exhibits anticancer chemotherapeutic activity. Nedaplatin is a DNA cross-linking agent that acts by binding the N7 position on guanine residues, inhibiting DNA synthesis and repair.
| Cas No. | 95734-82-0 |
|---|---|
| Purity | ≥98% |
| Formula | C2H8N2O3Pt |
| Formula Wt. | 303.18 |
| IUPAC Name | azanide;2-hydroxyacetic acid;platinum(2+) |
| Melting Point | 130°C |
| Appearance | Off white to pale yellow green powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Yuan G, Wu L, Huang M, et al. A phase II study of concurrent chemo-radiotherapy with weekly nedaplatin in advanced squamous cell carcinoma of the uterine cervix. Radiat Oncol. 2014 Feb 18;9:55. PMID: 24533532.
Ali I, Wani WA, Saleem K, et al. Platinum compounds: a hope for future cancer chemotherapy. Anticancer Agents Med Chem. 2013 Feb;13(2):296-306. PMID: 22583420.
Poklar N, Pilch DS, Lippard SJ, et al. Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex. Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7606-11. PMID: 8755522.
