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CPI-203

Product ID C6132
Cas No. 1446144-04-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $102.20 In stock
5 mg $314.60 In stock
25 mg $1,101.20 In stock
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  • Description
  • Product Info
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  • Description
  • Product Info
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  • References
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Description

CPI-203 is an orally available derivative of triazolothienodiazepine JQ-1; it exhibits no sedative or anxiolytic efficacy and is currently in development as a potential anticancer compound. Like JQ-1, CPI-203 inhibits the BET bromodomain (BRD) family of proteins, including BRD4; inhibition of this protein downregulates Myc expression and IL-6 production in vitro. This compound also inhibits phosphorylation of the carboxyl-terminus domain of RNA polymerase II.

Product Info

Cas No.

1446144-04-2

Purity

≥99%

Formula

C19H18ClN5OS

Formula Wt.

399.90

Melting Point

151.8°C

Solubility

DMSO 79 mg/mL warmed (197.54 mM) Ethanol 5 mg/mL (12.5 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C6132 MSDS PDF

Info Sheet

C6132 Info Sheet PDF

References

King B, Trimarchi T, Reavie L, et al. The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell. 2013 Jun 20;153(7):1552-66. PMID: 23791182.

Devaiah BN, Lewis BA, Cherman N, et al. BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6927-32. PMID: 22509028.

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