Glucagon-like Peptide II, rat

Product ID G4484

Cas No. 195262-56-7

Purity ≥95%

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Description
Product Info
Shipping and Storage
Downloads
References

Description
Product Info
Shipping and Storage
Downloads
References
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Description

Glucagon-like peptide 2 (GLP-2) is an endogenous peptide hormone primarily synthesized in the intestine and pancreas. GLP-2 binds and activates the GLP-2 receptor, exhibiting vasodilatory, antihypertensive, antidepressant, and gastrointestinal motility modulating activities. In animal models, GLP-2 increases intestinal blood flow and decreases mean arterial blood pressure. GLP-2 potentiates L-type voltage-gated Ca2+ channels through a mechanism that involves activation of PKA. Additionally, GLP-2 decreases immobility time in animals undergoing the forced swim test. This peptide stimulates cell proliferation, inhibiting chemotherapy-induced mucosal atrophy in the intestines. GLP-2 also decreases gastric emptying and gastrointestinal motility.

Product Info

Cas No.	195262-56-7
Purity	≥95%
Formula	C₁₆₆H₂₅₆N₄₄O₅₆S
Formula Wt.	3796.22
Synonym	GLP-2
Solubility	Soluble in water (1 mg/mL).
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	G4484 MSDS PDF
Info Sheet	G4484 Info Sheet PDF

References

Sasaki-Hamada S, Ito K, Oka JI. Neuronal Fos-like immunoreactivity associated with dexamethasone-induced hypertension in rats and effects of glucagon-like peptide-2. Life Sci. 2013 Oct 24. pii: S0024-3205(13)00618-8. [Epub ahead of print]. PMID: 24513200.

Hansen LB. GLP-2 and mesenteric blood flow. Dan Med J. 2013 May;60(5):B4634. PMID: 23673268.

Rasmussen AR, Viby NE, Hare KJ, et al. The intestinotrophic peptide, GLP-2, counteracts the gastrointestinal atrophy in mice induced by the epidermal growth factor receptor inhibitor, erlotinib, and cisplatin. Dig Dis Sci. 2010 Oct;55(10):2785-96. PMID: 20112065.

Wang Y, Guan X. GLP-2 potentiates L-type Ca2+ channel activity associated with stimulated glucose uptake in hippocampal neurons. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E156-66. PMID: 19920220.

Iwai T, Hayashi Y, Narita S, et al. Antidepressant-like effects of glucagon-like peptide-2 in mice occur via monoamine pathways. Behav Brain Res. 2009 Dec 1;204(1):235-40. PMID: 19539656.

Mojsov S, Kopczynski MG, Habener JF. Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem. 1990 May 15;265(14):8001-8. PMID: 1692320.