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Astragaloside IV

Product ID A7578
Cas No. 83207-58-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $228.10 In stock
25 mg $456.60 In stock
100 mg $1,368.80 In stock
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Description

Astragaloside IV is an active compound found in Astragalus membranaceus that exhibits cardioprotective, antioxidative, and pro-angiogenic activities. Astragaloside IV prevents LPS-induced increases in Ca2+, activation of CaN and GATA-4, and nuclear factor of activated T cells 3 (NFAT3) translocation, inhibiting cardiac hypertrophy. Additionally, astragaloside IV decreases expression of matrix metalloproteinase 9 (MMP-9) and prevents ischemia/reperfusion-induced myocardial infarction and myocardial apoptosis in animal models. In other animals, astragaloside IV prevented increases in ROS, pro-inflammatory cytokines, and downregulation of superoxide dismutase (SOD), glutathione, and tau phosphorylation induced by experimental autoimmune encephalitis (EAE); this compound also prevents related decreases in the Bcl-2/Bax ratio and changes in T cell differentiation and migration. In endothelial cells, astragaloside IV activates JAK/STAT and ERK 1/2 signaling and upregulates production of eNOS and NO, promoting tube/vessel formation.

Product Info

Cas No.

83207-58-3

Purity

≥98%

Formula

C41H68O14

Formula Wt.

784.97

Chemical Name

(2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

IUPAC Name

(2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

Synonym

Astragaloside A, Cyclosiversioside F

Melting Point

295-296°C

Solubility

Soluble in DMSO (10 mg/mL), ethanol. Insoluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A7578 MSDS PDF

Info Sheet

A7578 Info Sheet PDF

References

Lu M, Wang H, Wang J, et al. Astragaloside IV Protects against Cardiac Hypertrophy via Inhibiting the Ca2+/CaN Signaling Pathway. Planta Med. 2013 Dec 11. [Epub ahead of print]. PMID: 24338553.

Wang SG, Xu Y, Chen JD, et al. Astragaloside IV stimulates angiogenesis and increases nitric oxide accumulation via JAK2/STAT3 and ERK1/2 pathway. Molecules. 2013 Oct 16;18(10):12809-19. PMID: 24135938.

He Y, Du M, Gao Y, et al. Astragaloside IV attenuates experimental autoimmune encephalomyelitis of mice by counteracting oxidative stress at multiple levels. PLoS One. 2013 Oct 4;8(10):e76495. PMID: 24124567.

Li M, Ma RN, Li LH, et al. Astragaloside IV reduces cerebral edema post-ischemia/reperfusion correlating the suppression of MMP-9 and AQP4. Eur J Pharmacol. 2013 Sep 5;715(1-3):189-95. PMID: 23747593.

Tu L, Pan CS, Wei XH, et al. Astragaloside IV protects heart from ischemia and reperfusion injury via energy regulation mechanism. Microcirculation. 2013 Jun 28. [Epub ahead of print]. PMID: 23809007.

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