Name: CCT-245737
SKU: C104762
Availability: InStock

Description

CCT-245737 is an inhibitor of checkpoint kinase (CHK) 1. It is 1,000 fold selective for CHK1 over CHK2 and CDK1. It enhances the efficacy of gemcitabine in human tumor xenografts. It also shows potential as a monotherapy in a MYC-driven mouse model of B-cell lymphoma.

Product Info

Cas No.	1489389-18-5
Purity	≥98%
Formula	C₁₆H₁₆F₃N₇O
Formula Wt.	379.35
IUPAC Name	5-{[4-{[(2R)-2-Morpholinylmethyl]amino}-5-(trifluoromethyl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile
Synonym	CCT-245737, CCT 245737, CCT245737

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	C104762 MSDS PDF
Info Sheet	C104762 Info Sheet PDF

References

Walton M., Eve P., et al. The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma. Oncotarget. 7(3):2329-42 (2016). PMID: 26295308.

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CCT-245737

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