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CCT-245737

Product ID C104762
Cas No. 1489389-18-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $80.40 In stock
5 mg $154.60 In stock
25 mg $401.80 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

CCT-245737 is an inhibitor of checkpoint kinase (CHK) 1. It is 1,000 fold selective for CHK1 over CHK2 and CDK1. It enhances the efficacy of gemcitabine in human tumor xenografts. It also shows potential as a monotherapy in a MYC-driven mouse model of B-cell lymphoma.

Product Info

Cas No.

1489389-18-5

Purity

≥98%

Formula

C16H16F3N7O

Formula Wt.

379.35

IUPAC Name

5-{[4-{[(2R)-2-Morpholinylmethyl]amino}-5-(trifluoromethyl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile

Synonym

CCT-245737, CCT 245737, CCT245737

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C104762 MSDS PDF

Info Sheet

C104762 Info Sheet PDF

References

Walton M., Eve P., et al. The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma. Oncotarget. 7(3):2329-42 (2016). PMID: 26295308.

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