LKT Labs

Biochemicals for Life Science Research

4-bromo-A23187

Product ID A0101
Cas No. 76455-48-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $183.80 In stock
5 mg $751.70 In stock
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Description

This compound is a non-fluorescent halogenated analog of A23187. A23187 is a Ca2+ ionophore that exhibits pro-inflammatory and allergic activities. In cardiomyocytes, A23187 induces formation of endothelial microvesicles, increasing leakage of lactate dehydrogenase and decreasing cell viability. A23187 also induces mast cell degranulation and increases production of TNF-α. In spermatozoa, this compound induces the acrosome reaction, allowing fertilization to occur in the absence of PKA activation.

Product Info

Cas No.

76455-48-6
Purity

≥98%
Formula

C29H36BrN3O6
Formula Wt.

602.52
Chemical Name

IUPAC Name

6-bromo-5-(methylamino)-2-[[3,5, 9-trimethyl-2-[1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1, 7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid
Synonym

4-Bromo-A-23187, 4-BrA23187, 4-Bra23187
Solubility

DMSO (100 mg/mL), Methanol, Dichloromethane (10 mg/mL).
Appearance

Slight Yellow Crystals

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A0101 MSDS PDF
Info Sheet

A0101 Info Sheet PDF

References

Kim DY, Kang TB, Shim DW, et al. Emodin attenuates A23187-induced mast cell degranulation and tumor necrosis factor-α secretion through protein kinase C and IκB kinase 2 signaling. Eur J Pharmacol. 2014 Jan 15;723:501-6. PMID: 24239713.

Shang M, Zhang Q, Zhang MX, et al. Effects of endothelial microvesicles induced by A23187 on H9c2 cardiomyocytes. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Nov;29(6):559-64. PMID: 24654540.

Tateno H, Krapf D, Hino T, et al. Ca2+ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18543-8. PMID: 24128762.

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