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Cycloheximide

Product ID C9709
Cas No. 66-81-9
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $51.80 In stock
1 g $96.60 In stock
5 g $282.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cycloheximide was initially produced by Streptomyces. Cycloheximide inhibits protein synthesis in eukaryotes by preventing tRNA translocation and elongation. Cycloheximide is not used in humans due to its high toxicity. In research models, cycloheximide is used to determine protein lifespan and ribosomal profiling.

Product Info

Cas No.

66-81-9

Purity

≥98%

Formula

C15H23NO4

Formula Wt.

281.35

Chemical Name

[1S-[1αS*),3α,5β]]-4-[2-(3,5-Dimethyl-2-oxocyclo- hexyl)-2-hydroxyethyl]-2,6-piperidinedione

IUPAC Name

4-[(2R)-2-[(1S,3S,5S)-3, 5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione

Synonym

Naramycin A, Actidione, Naramycin, NSC-185, A-67, Zygomycin-D

Melting Point

119.5-121°C

Solubility

Soluble in chloroform, DMSO, acetone, methanol, or ethanol. Soluble in water to 20 mg/ml.

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C9709 MSDS PDF

Info Sheet

C9709 Info Sheet PDF

References

Bohnert M, Scherer O, Wiechmann K, et al. Melleolides induce rapid cell death in human primary monocytes and cancer cells. Bioorg Med Chem. 2014 Aug 1;22(15):3856-61. PMID: 25028062.

Ren Y, D'Ambrosio MA, Garvin JL, et al. Aldosterone sensitizes connecting tubule glomerular feedback via the aldosterone receptor GPR30. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F427-34. PMID: 24966088.

Greenberger NJ, Ruppert RD. Inhibition of protein synthesis: a mechanism for the production of impaired iron absorption. Science. 1966 Jul 15;153(3733):315-6. PMID: 17780009.

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