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Remdesivir

Product ID R176485
Cas No. 1809249-37-3
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $105.90 In stock
25 mg $347.30 In stock
100 mg $1,030.10 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Remdesivir is an antiviral compound used to inhibit the action of RNA polymerase. Remdesivir was originally investigated as a treatment for Ebola virus, but has potential to treat a variety of RNA viruses. Its activity against the coronavirus (CoV) family of viruses, such as SARS-CoV and MERS-CoV, was described in 2017, and it is also being investigated as a potential treatment for SARS-CoV-2 infections. (Pubchem)

Product Info

Cas No.

1809249-37-3

Purity

≥99%

Formula

C27H35N6O8P

Formula Wt.

602.6

Chemical Name

2-Ethylbutyl (2S)-2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

IUPAC Name

2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(phenoxy)phosphoryl]amino}propanoate

Synonym

GS 5734, GS-5734

Solubility

Soluble in DMSO. Insoluble in water.

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

R176485 MSDS PDF

Info Sheet

R176485 Info Sheet PDF

References

Warren TK, Jordan R, Lo MK, et.al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17;531(7594):381-5. doi: 10.1038/nature17180. Epub 2016 Mar 2. [PMID:26934220]

Sheahan TP, Sims AC, Graham RL, et.al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med. 2017 Jun 28;9(396). pii: 9/396/eaal3653. doi: 10.1126/scitranslmed.aal3653. [PMID:28659436]

Agostini ML, Andres EL, Sims AC, et.al Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. mBio. 2018 Mar 6;9(2). pii: mBio.00221-18. doi: 10.1128/mBio.00221-18. [PMID:29511076]

de Wit E, Feldmann F, Cronin J, et.al. Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Proc Natl Acad Sci U S A. 2020 Feb 13. pii: 1922083117. doi: 10.1073/pnas.1922083117. [PMID:32054787]

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