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ALLN

ALLN

Product ID A4646
Cas No. 110044-82-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $136.70 In stock
25 mg $501.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

ALLN is a tetrapeptide that inhibits proteases such as calpain I and II. ALLN also stimulates autophagy in vitro and suppresses IκB proteolysis. ALLN exhibits anticancer chemotherapeutic and chemopreventive potential, inducing apoptosis in colon cancer cells and inhibiting tumor formation in vivo.

Product Info

Cas No.

110044-82-1

Purity

≥98%

Formula

C20H37N3O4

Formula Wt.

383.53

IUPAC Name

2-acetamido-4-methyl-N-[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]pentanamide

Synonym

Calpain inhibitor 1, Ac-LLnL-CHO, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal

Melting Point

267.52°C (Predicted)

Solubility

Soluble in DMSO (10 mg/ml), ethanol (5 mg/ml), methanol, and DMSO. Insoluble in water, and aqueous buffers.

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A4646 MSDS PDF

Info Sheet

A4646 Info Sheet PDF

References

Kaneko Y, Murphy CR, Day ML. Calpain 2 activity increases at the time of implantation in rat uterine luminal epithelial cells and administration of calpain inhibitor significantly reduces implantation sites. Histochem Cell Biol. 2014 Apr;141(4):423-30. PMID: 24271063.

Chatterjee C, Sparks DL. Hepatic Lipase Release is Inhibited by a Purinergic Induction of Autophagy. Cell Physiol Biochem. 2014 Mar 28;33(4):883-894. PMID: 24713587.

Ariyadi B, Isobe N, Yoshimura Y. Toll-like receptor signaling for the induction of mucin expression by lipopolysaccharide in the hen vagina. Poult Sci. 2014 Mar;93(3):673-9. PMID: 24604861.

Li SZ, Zhang HH, Zhang JN, et al. ALLN hinders HCT116 tumor growth through Bax-dependent apoptosis. Biochem Biophys Res Commun. 2013 Jul 26;437(2):325-30. PMID: 23831472.

Custom Order

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