Description
MRTX1719 is an inhibitor of the PRMT5/MTA complex and may be effective against MTAP-deleted cancers.
MRTX1719
Product ID M704793
Cas No. 2630904-45-7
Purity ≥95%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 2630904-45-7 |
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| Purity | ≥95% |
| Formula | C23H18ClFN6O2 |
| IUPAC Name | 2-[4-[4-(aminomethyl)-1-oxo-2H-phthalazin-6-yl]-2-methylpyrazol-3-yl]-4-chloro-6-cyclopropyloxy-3-fluorobenzonitrile |
| Synonym | MRTX-1719 |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| Info Sheet |
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References
Smith C, Aranda R, Christensen J, et al. Design and evaluation of achiral, non-atropisomeric 4-(aminomethyl)phthalazin-1(2H)-one derivatives as novel PRMT5/MTA inhibitors. Bioorg Med Chem. 2022 Oct 1;71:116947. PMID: 35926325
Smith C, Aranda R, Bobinski T, et al. Fragment-based discovery of MRTX1719, a synthetic lethal inhibitor of the PRMT5.MTA complex for the treatment of MTAP-deleted cancers. J Med Chem. 2022 Feb 10;65(3):1749-1766. PMID: 35041419