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Idebenone

Idebenone

Product ID I1418
Cas No. 58186-27-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $71.70 In stock
25 mg $137.90 In stock
100 mg $325.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Idebenone is a synthetic quinone coenzyme Q (CoQ) analog that promotes mitochondrial respiration, increases ATP production, and inhibits lipoperoxide formation. Idebenone exhibits antioxidative, neuroprotective, cognition enhancing, cardioprotective, anti-inflammatory, and anti-fibrotic activities. In subjects with Alzheimer’s disease and in animal models of scopolamine-induced memory deficit, idebenone improves cognitive function and daily living aspects. Additionally, idebenone improves neurological function in subjects with Friedreich’s ataxia. In animal models of Duchennes Muscular Dystrophy (DMD), idebenone decreases cardiac inflammation and fibrosis and improves cardiac diastolic function and exercise performance.

Product Info

Cas No.

58186-27-9

Purity

≥98%

Formula

C19H30O5

Formula Wt.

338.44

Chemical Name

2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-benzoquinone

IUPAC Name

2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

Synonym

Avan, Daruma, Mnesis

Melting Point

46-50°C

Solubility

Soluble in organic solvents. Practically insoluble in water.

Appearance

Yellow-orange crystalline powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I1418 MSDS PDF

Info Sheet

I1418 Info Sheet PDF

References

Buyse GM, Van der Mieren G, Erb M, et al. Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance. Eur Heart J. 2009 Jan;30(1):116-24. PMID: 18784063.

Di Prospero NA, Baker A, Jeffries N, et al. Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial. Lancet Neurol. 2007 Oct;6(10):878-86. PMID: 17826341.

Gutzmann H, Kühl KP, Hadler D, et al. Safety and efficacy of idebenone versus tacrine in patients with Alzheimer's disease: results of a randomized, double-blind, parallel-group multicenter study. Pharmacopsychiatry. 2002 Jan;35(1):12-8. PMID: 11819153.

Liu XJ, Wu WT. Effects of ligustrazine, tanshinone II A, ubiquinone, and idebenone on mouse water maze performance. Zhongguo Yao Li Xue Bao. 1999 Nov;20(11):987-90. PMID: 11270979.

Suno M, Nagaoka A. Effect of idebenone and various nootropic drugs on lipid peroxidation in rat brain homogenate in the presence of succinate. Nihon Yakurigaku Zasshi. 1988 May;91(5):295-9. PMID: 3410376.

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