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Ozagrel Hydrochloride

Product ID O9702
Cas No. 82571-53-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $92.50 In stock
25 mg $185.30 In stock
100 mg $592.60 In stock
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  • Description
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Description

Ozagrel is an inhibitor of thromboxane A2 (TxA2) synthase that displays antithrombotic, anti-asthma, and anti-allergic activities. In vivo, ozagrel decreases airway responses to inhalation of leukotriene C4 (LTC4) and TxA2 analog STA2, inhibiting secondary release of TxA2. In other animal models of bronchoconstriction, ozagrel increases levels of prostaglandin I2 (PGI2), inhibiting histamine release. In clinical settings, ozagrel decreases airway contraction in subjects with exercise-induced asthma. In diabetic mice, this compound inhibits retinal arteriolar constriction, preventing decreases in retinal blood flow associated with diabetes-induced retinopathy. Additionally, ozagrel displays cardioprotective activity, decreasing infarct size and thrombus formation in animal models of ischemia-induced myocardial injury. Ozagrel is also hepatoprotective, inhibiting expression of Jun, Fos, and C/EBP homologous protein (CHOP), preventing acetaminophen-induced liver injury.

Product Info

Cas No.

82571-53-7

Purity

≥98%

Formula

C13H12N2O2 • HCl

Formula Wt.

264.71

IUPAC Name

(E)-3-[4-(imidazol-1-ylmethyl)phenyl]prop-2-enoic acid

Synonym

3-[4-(1H-imidazol-1-ylmethyl)phenyl]-2E-propenoic acid, OKY-046

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O9702 MSDS PDF

Info Sheet

O9702 Info Sheet PDF

References

Sathler PC, Santana M, Lourenço AL, et al. Human thromboxane synthase: comparative modeling and docking evaluation with the competitive inhibitors Dazoxiben and Ozagrel. J Enzyme Inhib Med Chem. 2013 Aug 5. Epub ahead of print. PMID: 23914925.

Tomishima Y, Ishitsuka Y, Matsunaga N, et al. Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice. BMC Gastroenterol. 2013 Jan 30;13:21. PMID: 23363429.

Lee S, Morgan GA, Harris NR. Ozagrel reverses streptozotocin-induced constriction of arterioles in rat retina. Microvasc Res. 2008 Nov;76(3):217-23. PMID: 18718478.

Fujimura M, Ogawa H, Saito M, et al. Inhibitory effect of inhalation of a thromboxane synthetase inhibitor on bronchoconstriction induced by aerosolized leukotriene C4 and thromboxane A2 analogue in anesthetized guinea pigs. Allergy. 1991 Oct;46(7):534-9. PMID: 1796779.

Hoshino M, Fukushima Y. Effect of OKY-046 (thromboxane A2 synthetase inhibitor) on exercise-induced asthma. J Asthma. 1991;28(1):19-29. PMID: 1849133.

Nambu F, Murakata S, Shiraji T, et al. OKY-046 inhibits anaphylactic bronchoconstriction and reduces histamine level in bronchoalveolar lavage fluid in sensitized guinea pigs. Prostaglandins. 1990 Jun;39(6):623-37. PMID: 1695383.

Tomoda H. Development of an experimental model of acute myocardial infarction and the effects of a thromboxane synthetase inhibitor (OKY-046). Am Heart J. 1986 Oct;112(4):696-704. PMID: 3532743.

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