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Methimazole

Methimazole

Product ID M1976
Cas No. 60-56-0
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $47.30 In stock
25 g $71.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Methimazole is a thioamide immunomodulatory anti-thyroid compound that is clinically used to treat hyperthyroidism and Graves’ disease. Methimazole is an irreversible inhibitor of thyroid peroxidase; it decreases levels of CXCL10 and downregulates expression of IFNγ receptors.

Product Info

Cas No.

60-56-0

Purity

≥98%

Formula

C4H6N2S

Formula Wt.

114.17

Chemical Name

1,3-Dihydro-1-methyl-2H-imidazole-2-thione

IUPAC Name

3-methyl-1H-imidazole-2-thione

Synonym

Basolan, Favistan, Frentirox, Mercazole, Tapazole, Thycapsol, Strumazol

Melting Point

146-148°C

Solubility

Soluble in water (200 mg/mL), ethanol (200 mg/mL), or chloroform. Slightly soluble in ether or benzene.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M1976 MSDS PDF

Info Sheet

M1976 Info Sheet PDF

References

Rivkees SA. Pediatric Graves' disease: management in the post-propylthiouracil Era. Int J Pediatr Endocrinol. 2014;2014(1):10. PMID: 25089127.

Manna D, Roy G, Mugesh G. Antithyroid drugs and their analogues: synthesis, structure, and mechanism of action. Acc Chem Res. 2013 Nov 19;46(11):2706-15. PMID: 23883148.

Crescioli C, Cosmi L, Borgogni E, et al. Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. J Endocrinol. 2007 Oct;195(1):145-55. PMID: 17911406.

Custom Order

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