Procaterol Hydrochloride

Name: Procaterol Hydrochloride
SKU: P7056
Availability: InStock

Product ID P7056

Cas No. 62929-91-3

Purity ≥98%

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Product Info
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References

Description

Procaterol is an agonist at β2-adrenergic receptors that exhibits anti-inflammatory, anti-asthma, and bronchodilatory activities. Procaterol is used to treat asthma. In animal models, procaterol suppresses anaphylactic reactions. In bronchial epithelial cells, procaterol inhibits release of RANTES, GM-CSF, and IL-8, inhibiting eosinophil chemotaxis. Additionally, procaterol decreases expression of intracellular adhesion molecule 1 (ICAM-1) and vascular cellular adhesion molecule 1 (VCAM-1), inhibiting adhesion of eosinophils to fibroblasts.

Product Info

Cas No.	62929-91-3
Purity	≥98%
Formula	C₁₆H₂₂N₂O₃ • HCl
Formula Wt.	326.82
IUPAC Name	8-hydroxy-5-[(1R, 2S)-1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one;hydrochloride
Synonym	Meptin, Lontermin
Melting Point	213-215C
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	P7056 MSDS PDF
Info Sheet	P7056 Info Sheet PDF

References

Bao W, Chen Q, Lin Y, et al. Efficacy of procaterol combined with inhaled budesonide for treatment of cough-variant asthma. Respirology. 2013 Nov;18 Suppl 3:53-61. PMID: 24188204.

Yoshida N, Muraguchi M, Kamata M, et al. Procaterol potentiates the anti-inflammatory activity of budesonide on eosinophil adhesion to lung fibroblasts. Int Arch Allergy Immunol. 2009;150(4):352-8. PMID: 19571567.

Koyama S, Sato E, Masubuchi T, et al. Procaterol inhibits IL-1beta- and TNF-alpha-mediated epithelial cell eosinophil chemotactic activity. Eur Respir J. 1999 Oct;14(4):767-75. PMID: 10573218.

Ohuchi K, Hirasawa N, Takeda H, et al. Mechanism of antianaphylactic action of beta-agonists in allergic inflammation of air pouch type in rats. Int Arch Allergy Appl Immunol. 1987;82(1):26-32. PMID: 2879797.