Myomodulin

Name: Myomodulin
SKU: M9356
Availability: InStock

Product ID M9356

Cas No. 110570-93-9

Purity ≥95%

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Product Info
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References

Description

Myomodulin is a neuromodulatory peptide found in molluscs, insects, and gastropods. In leeches, myomodulin inhibits activity of the Na+/K+ pump, increasing hyperpolarization-activated current I(h) and altering heart neuron spike and burst frequency. In glial cell membranes, myomodulin evokes membrane outward currents and elicits increases in K+ conductance. Across many cellular models, myomodulin modulates K+, Na+, and Ca2+ current amplitudes. Additionally, myomodulin increases muscle contraction frequency, increasing gut motility.

Product Info

Cas No.	110570-93-9
Purity	≥95%
Formula	C₃₆H₆₇N₁₁O₈S₂
Formula Wt.	846.13
IUPAC Name	(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]pyrrolidine-2-carboxamide
Synonym	Myomodulin A , Myomoduline A
Solubility	Soluble in water.
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

Info Sheet	M9356 Info Sheet PDF

References

Tobin AE, Calabrese RL. Myomodulin increases Ih and inhibits the NA/K pump to modulate bursting in leech heart interneurons. J Neurophysiol. 2005 Dec;94(6):3938-50. PMID: 16093342.

Britz FC, Deitmer JW. Membrane responses of the leech giant glial cell to the peptide transmitter myomodulin. Peptides. 2002 Dec;23(12):2117-25. PMID: 12535690.

Wang Y, Strong JA, Sahley CL. Modulatory effects of myomodulin on the excitability and membrane currents in Retzius cells of the leech. J Neurophysiol. 1999 Jul;82(1):216-25. PMID: 10400950.

Perry SJ, Straub VA, Kemenes G, et al. Neural modulation of gut motility by myomodulin peptides and acetylcholine in the snail Lymnaea. J Neurophysiol. 1998 May;79(5):2460-74. PMID: 9582220.