RITA

Name: RITA
SKU: R3476
Availability: InStock

Product ID R3476

Cas No. 213261-59-7

Purity ≥98%

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Description

Reactivation of p53 and induction of tumor cell apoptosis (RITA) is an activator of p53 that exhibits anticancer chemotherapeutic and anti-angiogenic activities. In vivo, RITA downregulates expression of VEGF, HIF-1α, p21, and HDM2. In cellular and animal models of neuroblastoma, RITA inhibits expression of N-Myc, AurK, Mcl-1, Bcl-2, MDM2, and MDMX, inducing apoptosis and inhibiting growth. Similar effects are observed in models of gastrointestinal stromal tumors and cervical carcinoma.

Product Info

Cas No.	213261-59-7
Purity	≥98%
Formula	C₁₄H₁₂O₃S₂
Formula Wt.	292.37
Chemical Name	[5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
IUPAC Name	[5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol
Synonym	NSC 652287; RITA (NSC 652287); p53 Activator III, RITAReactivation of p53 and induction of tumor cell apoptosis
Solubility	Soluble in DMSO (58 mg/ml at 25° C), ethanol (8 mg/ml at 25° C), DMF (30 mg/ml), 1:1 solution of dimethyl formamide: PBS (pH 7.2) (0.5 mg/ml, dissolve RITA first in dimethyl formamide and then dilute with PBS), and water (<1 mg/ml at 25° C).

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	R3476 MSDS PDF
Info Sheet	R3476 Info Sheet PDF

References

Burmakin M, Shi Y, Hedström E, et al. Dual targeting of wild-type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro. Clin Cancer Res. 2013 Sep 15;19(18):5092-103. PMID: 23864164.

Henze J, Mühlenberg T, Simon S, et al. p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors. PLoS One. 2012;7(5):e37776. PMID: 22662219.

Zhao CY, Szekely L, Bao W, et al. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 2010 Apr 15;70(8):3372-81. PMID: 20395210.

Yang J, Ahmed A, Poon E, et al. Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxia. Mol Cell Biol. 2009 Apr;29(8):2243-53. PMID: 19223463.