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Nefazodone Hydrochloride

Nefazodone Hydrochloride

Product ID N1822
Cas No. 82752-99-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $97.10 In stock
5 g $416.90 In stock
25 g $1,327.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Nefazodone is an atypical antidepressant that inhibits 5-HT2 receptors, serotonin transporters (SERT), norepinephrine transporters (NET), and human ether-a-go-go-related (hERG) K+ channels. Nefazodone decreases immobility time in the forced swim test and is clinically used to treat depression, panic disorder, and post-traumatic stress disorder (PTSD).

Product Info

Cas No.

82752-99-6

Purity

≥98%

Formula

C25H32ClN5O2 • HCl

Formula Wt.

506.48

Chemical Name

2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5- ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride

IUPAC Name

2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2- phenoxyethyl)-1,2,4-triazol-3-one;hydrochloride

Synonym

BMY-13754, MJ-13754-1, Dutonin, Serzone

Melting Point

186-187°C

Solubility

Slightly soluble in water.

Appearance

A White to off-White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

N1822 MSDS PDF

Info Sheet

N1822 Info Sheet PDF

References

Shin DS, Park MJ, Lee HA, et al. A novel assessment of nefazodone-induced hERG inhibition by electrophysiological and stereochemical method. Toxicol Appl Pharmacol. 2014 Feb 1;274(3):361-71. PMID: 24374264.

Clayton AH, Montejo AL. Major depressive disorder, antidepressants, and sexual dysfunction. J Clin Psychiatry. 2006;67 Suppl 6:33-7. PMID: 16848675.

Dremencov E, Gispan-Herman I, Rosenstein M, et al. The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan;28(1):141-7. PMID: 14687868.

Eckler JR, Rabin RA, Winter JC. Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control. Pharmacol Biochem Behav. 2003 May;75(2):405-10. PMID: 12873632.

Custom Order

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  • This field is for validation purposes and should be left unchanged.

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