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Nefazodone is an atypical antidepressant that inhibits 5-HT2 receptors, serotonin transporters (SERT), norepinephrine transporters (NET), and human ether-a-go-go-related (hERG) K+ channels. Nefazodone decreases immobility time in the forced swim test and is clinically used to treat depression, panic disorder, and post-traumatic stress disorder (PTSD).
| Cas No. | 82752-99-6 |
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| Purity | ≥98% |
| Formula | C25H32ClN5O2 • HCl |
| Formula Wt. | 506.48 |
| Chemical Name | 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5- ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride |
| IUPAC Name | 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2- phenoxyethyl)-1,2,4-triazol-3-one;hydrochloride |
| Synonym | BMY-13754, MJ-13754-1, Dutonin, Serzone |
| Melting Point | 186-187°C |
| Solubility | Slightly soluble in water. |
| Appearance | A White to off-White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Shin DS, Park MJ, Lee HA, et al. A novel assessment of nefazodone-induced hERG inhibition by electrophysiological and stereochemical method. Toxicol Appl Pharmacol. 2014 Feb 1;274(3):361-71. PMID: 24374264.
Clayton AH, Montejo AL. Major depressive disorder, antidepressants, and sexual dysfunction. J Clin Psychiatry. 2006;67 Suppl 6:33-7. PMID: 16848675.
Dremencov E, Gispan-Herman I, Rosenstein M, et al. The serotonin-dopamine interaction is critical for fast-onset action of antidepressant treatment: in vivo studies in an animal model of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan;28(1):141-7. PMID: 14687868.
Eckler JR, Rabin RA, Winter JC. Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control. Pharmacol Biochem Behav. 2003 May;75(2):405-10. PMID: 12873632.
