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Psoralen

Product ID P7358
Cas No. 66-97-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $125.50 In stock
25 mg $251.10 In stock
100 mg $684.50 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
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Description

Psoralen is a furanocoumarin compound originally found in Psoralea coryfolia that exhibits anti-angiogenic activity. Psoralen is currently used to treat psoriasis with the additional of UVA light. Psoralen inhibits angiogenesis and induces G0/G1 phase cell cycle arrest and apoptosis in endothelial cells. This compound also inhibits topoisomerase I and induces DNA interstrand crosslinks and monoadducts, displaying carcinogenic potential as well.

Product Info

Cas No.

66-97-7

Purity

≥98%

Formula

C11H6O3

Formula Wt.

186.16

Chemical Name

furo[3,2-g]chromen-7-one

IUPAC Name

furo[3,2-g]chromen-7-one

Synonym

Ficusin

Melting Point

163-164°C

Solubility

Soluble in ethanol (10 mg/ml), ethyl acetate, acetone, and water (1.93 mg/ml at 25 °C).

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P7358 MSDS PDF

Info Sheet

P7358 Info Sheet PDF

References

Chopra B, Dhingra AK, Dhar KL. Psoralea corylifolia L. (Buguchi) - folklore to modern evidence: review. Fitoterapia. 2013 Oct;90:44-56. PMID: 23831482.

Diwan R, Malpathak N. Furanocoumarins: novel topoisomerase I inhibitors from Ruta graveolens L. Bioorg Med Chem. 2009 Oct 1;17(19):7052-5. PMID: 19736019.

Derheimer FA, Hicks JK, Paulsen MT, et al. Psoralen-induced DNA interstrand cross-links block transcription and induce p53 in an ataxia-telangiectasia and rad3-related-dependent manner. Mol Pharmacol. 2009 Mar;75(3):599-607. PMID: 19064630.

Deng H, Yan CL, Hu Y, et al. Photochemotherapy inhibits angiogenesis and induces apoptosis of endothelial cells in vitro. Photodermatol Photoimmunol Photomed. 2004 Aug;20(4):191-9. PMID: 15238097.

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