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[Sar1]-Angiotensin II

Product ID A5283
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $74.10 In stock
10 mg $126.00 In stock
25 mg $222.50 Please Inquire
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Angiotensin II (AT II) is a peptide produced from AT I by angiotensin-converting-enzyme (ACE). AT II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels; this results in contraction and vasoconstriction, increasing blood pressure. AT II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney. Here, AT II increases reabsorption of Na+ and HCO3- and excretion of H+, increasing blood volume and pH and further increasing blood pressure.

Product Info

Purity

≥95%

Formula

C49H71N13O11

Formula Wt.

1018.19

Solubility

Soluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A5283 MSDS PDF

Info Sheet

A5283 Info Sheet PDF

References

De Giusti VC, Ciancio MC, Orlowski A, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. PMID: 24478712.

Moon JY. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-45. PMID: 24627703.

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