LKT Labs

Biochemicals for Life Science Research

Penicillic Acid

Product ID P1854
Cas No. 90-65-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $87.40 In stock
10 mg $234.50 In stock
50 mg $651.50 In stock
Bulk Quote

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Description

Penicillic acid is a neuroactive mycotoxin initially produced by species of Penicillum and Aspergillus. In vitro and in vivo, penicillic acid inhibits Ca2+sensitive (BK) K+ channels as well as Na+, K+, and Ca2+ channels in cardiac tissue. Penicillic acid exhibits antifungal and anti-apoptotic activities. In vitro, penicillic acid increases expression of histone demethylase JMJD-3 and decreases expression of histone deacetylase 3 (HDAC3), inhibiting proliferation of macrophages. Penicillic acid inhibits FasL-induced apoptosis, preventing activation of caspases 3 and 9 through inhibition of upstream signaling and also preventing activation of caspase 8 through direct inhibition. Additionally, this compound induces abnormal branching and swelling in species of Phytophthora.

Product Info

Cas No.

90-65-3
Purity

≥98%
Formula

C8H10O4
Formula Wt.

170.16
IUPAC Name

(2E)-3-methoxy-5-methyl-4-oxohexa-2,5-dienoic acid
Melting Point

83-87°C
Solubility

Water, Ethanol, Dichloromethane.
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

P1854 MSDS PDF
Info Sheet

P1854 Info Sheet PDF

References

Oh SY, Balch CG, Cliff RL, et al. Exposure to Penicillium mycotoxins alters gene expression of enzymes involved in the epigenetic regulation of bovine macrophages (BoMacs). Mycotoxin Res. 2013 Nov;29(4):235-43. PMID: 23893597.

Kang SW, Kim SW. New antifungal activity of penicillic acid against Phytophthora species. Biotechnol Lett. 2004 May;26(9):695-8. PMID: 15195966.

Bando M, Hasegawa M, Tsuboi Y, et al. The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex. J Biol Chem. 2003 Feb 21;278(8):5786-93. PMID: 12482880.

Pandiyan V, Nayeem M, Nanjappan K, et al. Penicillic acid as Na+,K+ and Ca2+ channel blocker in isolated frog's heart at toxic levels. Indian J Exp Biol. 1990 Mar;28(3):295-6. PMID: 2163978.

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