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Vasoactive intestinal peptide (VIP) is an endogenous peptide hormone that exhibits bronchodilatory, vasodilatory, and immunomodulatory activities. VIP increases levels of IL-10, Foxp3, and TGF-β in vivo and prevents LPS-induced expression of IL-6 and MCP-1 in vitro. VIP appears to play a significant role in respiratory inflammation.
| Cas No. | 40077-57-4 |
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| Purity | ≥95% |
| Formula | C147H238N44O42S |
| Formula Wt. | 3325.8 |
| Chemical Name | Vasoactive Intestinal Peptide |
| Solubility | Soluble in 1% acetic acid. |
| Appearance | White to Off-white Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Hauk V, Azzam S, Calo G, et al. Vasoactive intestinal Peptide induces an immunosuppressant microenvironment in the maternal-fetal interface of non-obese diabetic mice and improves early pregnancy outcome. Am J Reprod Immunol. 2014 Feb;71(2):120-30. PMID: 24405265.
Fraccaroli L, Grasso E, Hauk V, et al. Contribution of Vasoactive Intestinal Peptide to Immune Homeostasis in Trophoblast-Maternal Leukocyte Interaction under LPS Stimulation. Neuroimmunomodulation. 2014;21(1):21-30. PMID: 24135863.
Mathioudakis A, Chatzimavridou-Grigoriadou V, Evangelopoulou E, et al. Vasoactive intestinal Peptide inhaled agonists: potential role in respiratory therapeutics. Hippokratia. 2013 Jan;17(1):12-6. PMID: 23935337.