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Captopril is the first angiotensin-converting enzyme (ACE) inhibitor marketed; it is clinically used to treat hypertension, congestive heart failure (CHF), and diabetic nephropathy. Captopril exhibits antihypertensive, anti-metastatic, and anticancer chemotherapeutic activities. In animal models of lung cancer, captopril decreases tumor growth and metastasis and induces cellular apoptosis.
| Cas No. | 62571-86-2 |
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| Purity | ≥81% |
| Formula | C9H15NO3S |
| Formula Wt. | 217.29 |
| Chemical Name | N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline |
| IUPAC Name | (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid |
| Synonym | (2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline, Aceplus, Hypertil,Tensoprel |
| Melting Point | 104-108°C |
| Solubility | Soluble in water or ethanol. |
| Appearance | A White to Off-White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zidane F, Zeder-Lutz G, Altschuh D, et al. Surface plasmon resonance analysis of the binding mechanism of pharmacological and peptidic inhibitors to human somatic angiotensin I-converting enzyme. Biochemistry. 2013 Dec 3;52(48):8722-31. PMID: 24168709.
Attoub S, Gaben AM, Al-Salam S, et al. Captopril as a potential inhibitor of lung tumor growth and metastasis. Ann N Y Acad Sci. 2008 Sep;1138:65-72. PMID: 18837885.