LKT Labs

Biochemicals for Life Science Research

Cerivastatin Sodium

Product ID C1668
Cas No. 143201-11-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $201.70 In stock
10 mg $354.30 Please Inquire
25 mg $686.70 Please Inquire
Bulk Quote

Quicklinks

Description

Cerivastatin is an inhibitor of HMG-CoA reductase that exhibits anti-hyperlipidemic, anti-atherosclerotic, anti-fibrotic, and anti-inflammatory activities. Cerivastatin has been used clinically to lower cholesterol and treat cardiovascular disease, but has since been withdrawn from the market due to associations with the development of rhabdomyolysis. In vitro, cerivastatin decreases production and activation of IL-6, AP-1, and NF-κB. In hepatocytes, this compound decreases TNF-α-induced production of PAI-1, preventing atherosclerosis and fibrosis.

Product Info

Cas No.

143201-11-0
Purity

≥98%
Formula

C26H33FNO5Na
Formula Wt.

481.53
Chemical Name

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6- heptenoic acid
IUPAC Name

sodium;(E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2, 6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoate
Synonym

Baycol, Lipobay, Rivastatin
Solubility

Soluble in water.

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

C1668 MSDS PDF
Info Sheet

C1668 Info Sheet PDF
Brochures

Statins Flyer

References

Takeshita Y, Takamura T, Hamaguchi E, et al. Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line. Metabolism. 2006 Nov;55(11):1464-72. PMID: 17046548.

Schachter M. Chemical, pharmacokinetic and pharmacodynamic properties of statins: an update. Fundam Clin Pharmacol. 2005 Feb;19(1):117-25. PMID: 15660968.

Jamal SM, Eisenberg MJ, Christopoulos S. Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors. Am Heart J. 2004 Jun;147(6):956-65. PMID: 15199341.

Viedt C, Shen W, Fei J, et al. HMG-CoA reductase inhibition reduces the proinflammatory activation of human vascular smooth muscle cells by the terminal complement factor C5b-9. Basic Res Cardiol. 2003 Nov;98(6):353-61. PMID: 14556080.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.