Description
TTP 22 is an inhibitor of casein kinase 2 (CK2) that may alter cell survival, cell cycle control, DNA repair, and Wnt signaling; it is likely in development for potential anticancer activity.
Product Info
| Cas No. | 329907-28-0 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14N2O2S2 |
| Formula Wt. | 330.42 |
| IUPAC Name | 3-{[5-(4-Methylphenyl)thieno[2,3-d]pyrimidin-4-yl]sulfanyl}propanoic acid |
| Solubility | ethanol 20mM DMSO 100mM |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Golub AG, Bdzhola VG, Briukhovetska NV, et al. Synthesis and biological evaluation of substituted (thieno[2,3-d]pyrimidin-4-ylthio)carboxylic acids as inhibitors of human protein kinase CK2. Eur J Med Chem. 2011 Mar;46(3):870-6. PMID: 21276643.
Gao Y, Wang HY. Casein kinase 2 Is activated and essential for Wnt/beta-catenin signaling. J Biol Chem. 2006 Jul 7;281(27):18394-400. PMID: 16672224.