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20R-Ginsenoside Rh2

Product ID G3558
Cas No. 112246-15-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $111.70 In stock
5 mg $270.40 In stock
10 mg $461.10 In stock
25 mg $921.60 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ginsenoside Rh2 is a triterpene saponin found in Panax (ginseng) that exhibits immunomodulatory, neuroprotective, cognition enhancing, anti-inflammatory, antioxidative, and anticancer activities. In CD8+ T cells, ginsenoside Rh2 increases production of IFN-γ and activation of p38 MAPK and ERK, resulting in an increase in cell proliferation. In animals undergoing the Morris water maze test, ginsenoside Rh2 improves spatial learning and memory. This compound also modulates expression of inflammatory markers, decreasing expression of toll-like receptor 4 (TLR4), CD14, TNF-α, IL-1α and HIF-1α, and inhibiting degradation of IκB kinase and translocation of NF-κB across various cellular models.

Product Info

Cas No.

112246-15-8

Purity

≥98%

Formula

C36H62O8

Formula Wt.

622.87

IUPAC Name

(2R,3R,4S,5S,6R)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol

Synonym

Ginsenoside Rh2

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G3558 MSDS PDF

Info Sheet

G3558 Info Sheet PDF

References

Lv S, Yi PF, Shen HQ, et al. Ginsenoside Rh2-B1 stimulates cell proliferation and IFN-γ production by activating the p38 MAPK and ERK-dependent signaling pathways in CTLL-2 cells. Immunopharmacol Immunotoxicol. 2013 Dec 3. [Epub ahead of print]. PMID: 24294901.

Hou J, Xue J, Lee M, et al. Ginsenoside Rh2 improves learning and memory in mice. J Med Food. 2013 Aug;16(8):772-6. PMID: 23957360.

Tang XP, Tang GD, Fang CY, et al. Effects of ginsenoside Rh2 on growth and migration of pancreatic cancer cells. World J Gastroenterol. 2013 Mar 14;19(10):1582-92. PMID: 23538603.

Lian LH, Jin Q, Song SZ, et al. Ginsenoside Rh2 Downregulates LPS-Induced NF-κB Activation through Inhibition of TAK1 Phosphorylation in RAW 264.7 Murine Macrophage. Evid Based Complement Alternat Med. 2013;2013:646728. PMID: 23483870.

Choi WY, Lim HW, Lim CJ. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6. PMID: 23278699.

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