• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Irsogladine Maleate

Irsogladine Maleate

Product ID I7074
Cas No. 84504-69-8
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $139.00 In stock
500 mg $433.90 In stock
1 g $694.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Irsogladine exhibits anti-inflammatory, anti-fibrotic, and mucoprotective activities. Irsogladine decreases non-steroidal anti-inflammatory drug (NSAID)-induced intestinal mucosal injury, ulcers, and esophagitis; it inhibits COX-1 and COX-2. In animal models of colitis, irsogladine prevents DDS-induced increases in TGF-β1, collagen type 1, MMP2, TIMP-1, and α-SMA, preventing fibrosis. Additionally, irsogladine non-selectively inhibits phosphodiesterases, increasing cAMP and NO, facilitating gap junction communication and altering gastric mucosal blood flow.

Product Info

Cas No.

84504-69-8

Purity

≥98%

Formula

C9H7Cl2N5 • C4H4O4

Formula Wt.

372.17

Chemical Name

6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate

IUPAC Name

(Z)-but-2-enedioic acid;6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine

Synonym

MN-1695, Gaslon

Melting Point

289-294°C

Solubility

Soluble in DMSO.

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

I7074 MSDS PDF

Info Sheet

I7074 Info Sheet PDF

References

Kuramoto T, Umegaki E, Nouda S, et al. Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study. BMC Gastroenterol. 2013 May 14;13:85. PMID: 23672202.

Akagi M, Amagase K, Murakami T, et al. Irsogladine: overview of the mechanisms of mucosal protective and healing- promoting actions in the gastrointestinal tract. Curr Pharm Des. 2013;19(1):106-14. PMID: 22950502.

Yamaguchi H, Suzuki K, Nagata M, et al. Irsogladine maleate ameliorates inflammation and fibrosis in mice with chronic colitis induced by dextran sulfate sodium. Med Mol Morphol. 2012 Jun;45(3):140-51. PMID: 23001296.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • I7341

    Isoniazid

    Nicotinic acid derivative; InhA inhibitor.

    ≥98%
  • B3300

    BI-6727

    PLK1 inhibitor.

    ≥99%
  • T3357

    Tioconazole

    Imidazole; 14-α demethylase inhibitor.

    ≥98%
  • Z5653

    Zonisamide

    Sulfonamide; carbonic anhydrase inhibitor, volt...

    ≥96%
  • A2500

    AG-1478

    EGFR inhibitor.

    ≥98%
  • A0001

    A-803467

    Nav1.8 Na+ channel blocker, potential Nav1.5 Na...

    ≥97%
  • A0534

    Abiraterone

    Progesterone derivative; Cyp17A1 inhibitor.

    ≥99%
  • G4597

    18β-Glycyrrhetinic Acid

    Triterpene glycoside found in Glycyrrhiza; 15-H...

    ≥98%
  • A6368

    Aprepitant

    NK1 antagonist.

    ≥98%
  • T7676

    HT-2 Toxin

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%, TLC, HPLC
  • A7669

    A-type Natriuretic Peptide (1-28), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • S0048

    Salicin

    Alcoholic β-glucoside found in willow bark, sa...

    ≥98%
  • E6257

    Epothilone B

    Microtubule depolymerization inhibitor.

    ≥98%
  • D183738

    19-O-Demethyl rapamycin

    Fermentation impurity

    ≥97%
  • A5279

    Angiotensin II (1-4), human

    Endogenous peptide fragment, involved in vasoco...

    ≥95%
  • E6781

    (±)-Equol

    Isoflavone, phytoestrogen found in soy; ER agon...

    ≥98%
  • P0244

    Palbociclib Hydrochloride

    CDK4/6 inhibitor.

    ≥99%
  • A5283

    [Sar1]-Angiotensin II

    Peptide, derivative of AT II, involved in vasoc...

    ≥95%
  • M9368

    Myristicin

    Allylbenzene found in spices and umbelliferous ...

    ≥98%
  • D3575

    2,5-Di-tert-butyl-4-hydroxyanisole

    BHA derivative; potential Ca2+ ATPase inhibitor...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only