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A-803467

Product ID A0001
Cas No. 944261-79-4
Purity ≥97%
Product Unit SizeCostQuantityStock
10 mg $114.80 In stock
50 mg $398.00 In stock
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  • Product Info
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  • Description
  • Product Info
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  • References
  • Custom Order

Description

A-803467 is a blocker of Nav1.8 (SCN10A) Na+ channels that exhibits antinociceptive and antiarrhythmic activities; it may also block Nav1.5 (SCN5A) Na+ channels. A-803467 inhibits mechanical and thermal pain nociception in vivo. This compound also blocks cardiac Na+ currents and alters action potential morphology in ventricular myocytes.

Product Info

Cas No.

944261-79-4

Purity

≥97%

Formula

C19H16ClNO4

Formula Wt.

357.79

Chemical Name

5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide

IUPAC Name

5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide

Solubility

DMSO 72 mg/mL Ethanol 11 mg/mL Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A0001 MSDS PDF

Info Sheet

A0001 Info Sheet PDF

References

Rahman W, Dickenson AH. Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat. Neuroscience. 2015 Jun 4;295:103-16. PMID: 25818052.

Han Z, Jiang Y, Xiao F, et al. The effects of A-803467 on cardiac Nav1.5 channels. Eur J Pharmacol. 2015 May 5;754:52-60. PMID: 25701724.

Liu XD, Yang JJ, Fang D, et al. Functional upregulation of Nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain. PLoS One. 2014 Dec 11;9(12):e114623. PMID: 25503076.

Qi B, Wei Y, Chen S, et al. Nav1.8 channels in ganglionated plexi modulate atrial fibrillation inducibility. Cardiovasc Res. 2014 Jun 1;102(3):480-6. PMID: 24419303.

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