| Product Unit Size | Cost | Quantity | Stock |
|---|
A-803467 is a blocker of Nav1.8 (SCN10A) Na+ channels that exhibits antinociceptive and antiarrhythmic activities; it may also block Nav1.5 (SCN5A) Na+ channels. A-803467 inhibits mechanical and thermal pain nociception in vivo. This compound also blocks cardiac Na+ currents and alters action potential morphology in ventricular myocytes.
| Cas No. | 944261-79-4 |
|---|---|
| Purity | ≥97% |
| Formula | C19H16ClNO4 |
| Formula Wt. | 357.79 |
| Chemical Name | 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide |
| IUPAC Name | 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furamide |
| Solubility | DMSO 72 mg/mL Ethanol 11 mg/mL Water Insoluble |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Rahman W, Dickenson AH. Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat. Neuroscience. 2015 Jun 4;295:103-16. PMID: 25818052.
Han Z, Jiang Y, Xiao F, et al. The effects of A-803467 on cardiac Nav1.5 channels. Eur J Pharmacol. 2015 May 5;754:52-60. PMID: 25701724.
Liu XD, Yang JJ, Fang D, et al. Functional upregulation of Nav1.8 sodium channels on the membrane of dorsal root Ganglia neurons contributes to the development of cancer-induced bone pain. PLoS One. 2014 Dec 11;9(12):e114623. PMID: 25503076.
Qi B, Wei Y, Chen S, et al. Nav1.8 channels in ganglionated plexi modulate atrial fibrillation inducibility. Cardiovasc Res. 2014 Jun 1;102(3):480-6. PMID: 24419303.
