LKT Labs

Biochemicals for Life Science Research

25-Hydroxyvitamin D2

Product ID H9814
Cas No. 21343-40-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $361.10 Please Inquire
5 mg $1,555.60 In stock
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Description

25-hydroxyvitamin D2 (25-OH D2) is a metabolic product of ergocalciferol, or vitamin D2, an exogenously produced vitamin D dietary supplement. 25-OH D2 restores bone mineralization in vitamin D-deficient models and also regulates Ca2+ homeostasis as a downstream effect of the vitamin D signaling cascade. 25-OH D3 binds to the vitamin D receptor (VDR) but with lower affinity that 25-hydroxyvitamin D3 (25-OH D3). Potential mechanisms remain unknown, but low levels of 25-OH D2 are associated with Alzheimer’s disease in some studies.

Product Info

Cas No.

21343-40-8
Purity

≥98%
Formula

C28H44O2
Formula Wt.

412.65
Chemical Name

(E,3S,6S)-6-[(1R,3aR,4E,7aS)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidene-cyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2,3-dimethyl-hept-4-en-2-ol
IUPAC Name

(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5, 6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6, 7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
Melting Point

88.0-95.0°C
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

H9814 MSDS PDF
Info Sheet

H9814 Info Sheet PDF

References

Shah I, Petroczi A, Tabet N, et al. Low 25OH vitamin D2 levels found in untreated Alzheimer's patients, compared to acetylcholinesterase-inhibitor treated and controls. Curr Alzheimer Res. 2012 Nov;9(9):1069-76. PMID: 22876849.

Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006 Oct;84(4):694-7. PMID: 17023693.

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