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Butyric Acid Sodium

Product ID B8276
Cas No. 156-54-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $41.20 In stock
5 g $58.90 In stock
25 g $176.60 In stock
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  • Description
  • Product Info
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Description

Sodium butyrate is an inhibitor of histone deacetylases (HDACs) that exhibits antidepressant, immunomodulatory, and anticancer activities. In animals undergoing the light dark test, tail suspension test, and forced swim test, sodium butyrate decreases restraint stress-induced depression. In prostate cancer cells, this compound inhibits cell growth, induces apoptosis, downregulates expression of Bcl-xl and Bcl-2, and upregulates expression of Bak and Bax. Additionally, sodium butyrate decreases release of IL-12 and increases production of IL-23 in dendritic cells. Sodium butyrate also alters RNA splicing.

Product Info

Cas No.

156-54-7

Purity

≥98%

Formula

C4H7NaO2

Formula Wt.

110.09

IUPAC Name

sodium;butanoate

Synonym

Sodium butyrate, Sodium butanoate

Melting Point

250-253°C

Solubility

Soluble in water.

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B8276 MSDS PDF

Info Sheet

B8276 Info Sheet PDF

References

Han A, Sung YB, Chung SY, et al. Possible additional antidepressant-like mechanism of sodium butyrate: targeting the hippocampus. Neuropharmacology. 2014 Jun;81:292-302. PMID: 24607816.

Mu D, Gao Z, Guo H, et al. Sodium butyrate induces growth inhibition and apoptosis in human prostate cancer DU145 cells by up-regulation of the expression of annexin A1. PLoS One. 2013 Sep 23;8(9):e74922. PMID: 24086397.

Berndt BE, Zhang M, Owyang SY, et al. Butyrate increases IL-23 production by stimulated dendritic cells. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1384-92. PMID: 23086919.

Hnilicová J, Hozeifi S, Dušková E, et al. Histone deacetylase activity modulates alternative splicing. PLoS One. 2011 Feb 2;6(2):e16727. PMID: 21311748.

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