Curvularin is a macrocyclic lactone metabolite produced in several fungi. In a model of transgenic DBA/1 mice curvularin significantly reduced the expression of proinflammatory genes involved in the pathogenesis of collagen-induced arthritis and rheumatoid arthritis. In another study using human epithelial alveolar cell line A549/8 as the model, curvularin was shown to inhibit the cytokine-mixture-induced inducible-nitric-oxide-synthase promoter activity in a dose-dependent manner.
| Cas No. | 10140-70-2 |
|---|---|
| Purity | ≥98% |
| Formula | C16H20O5 |
| Formula Wt. | 292.33 |
| Chemical Name | (4S)-11,13-Dihydroxy-4-methyl-4,5,6,7,8,9-hexahydro-2H-3-benzoxacyclododecine-2,10(1H)-dione |
| IUPAC Name | (4S)-11,13-Dihydroxy-4-methyl-4,5,6,7,8,9-hexahydro-2H-3-benzoxacyclododecine-2,10(1H)-dione |
| Melting Point | 203-205°C |
| Solubility | Soluble in DMSO, ethanol, methanol and DMF. Insoluble in water. |
| Appearance | White powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| Info Sheet |
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Schmidt N, Art J, Forsch I, et al. The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis. J Pharmacol Exp Ther. 2012 Oct;343(1):106-114. PMID: 22767531.
Yao Y, Hausding M, Erkel G, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-391. PMID: 12527810.
Kumar CG, Mongolla P, Sujitha P, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated form Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122. PMID: 23565355.
