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Curvularin

Product ID C822706
Cas No. 10140-70-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $57.20 In stock
5 mg $238.60 In stock
25 mg $1,103.80 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

Curvularin is a macrocyclic lactone metabolite produced in several fungi. In a model of transgenic DBA/1 mice curvularin significantly reduced the expression of proinflammatory genes involved in the pathogenesis of collagen-induced arthritis and rheumatoid arthritis. In another study using human epithelial alveolar cell line A549/8 as the model, curvularin was shown to inhibit the cytokine-mixture-induced inducible-nitric-oxide-synthase promoter activity in a dose-dependent manner.

Product Info

Cas No.

10140-70-2

Purity

≥98%

Formula

C16H20O5

Formula Wt.

292.33

Chemical Name

(4S)-11,13-Dihydroxy-4-methyl-4,5,6,7,8,9-hexahydro-2H-3-benzoxacyclododecine-2,10(1H)-dione 

IUPAC Name

(4S)-11,13-Dihydroxy-4-methyl-4,5,6,7,8,9-hexahydro-2H-3-benzoxacyclododecine-2,10(1H)-dione

Melting Point

203-205°C

Solubility

Soluble in DMSO, ethanol, methanol and DMF. Insoluble in water.

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

C822706 MSDS PDF

Info Sheet

C822706 Info Sheet PDF

References

Schmidt N, Art J, Forsch I, et al. The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis. J Pharmacol Exp Ther. 2012 Oct;343(1):106-114. PMID: 22767531.

Yao Y, Hausding M, Erkel G, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-391. PMID: 12527810.

Kumar CG, Mongolla P, Sujitha P, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated form Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122. PMID: 23565355.

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