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2′,7-bis(triethylsilyl)taxol

Product ID T0120
Cas No. 135365-62-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $170.50 In stock
5 mg $477.00 In stock
10 mg $749.50 In stock
25 mg $1,499.10 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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Description

2′,7-bis(triethylsilyl)taxol is an intermediate in the synthesis of the anti-cancer therapeutic, taxol (paclitaxel) and its derivatives.

Product Info

Cas No.

135365-62-7

Purity

≥98%

Formula

C59H79NO14Si2

Formula Wt.

1082.44

Chemical Name

1-hydroxy-7β-triethylsilyloxy-9-oxo-10β-acetyloxy-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-benzoylamino-2-triethylsilyloxy-3-phenylpropanoate]

IUPAC Name

(2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-1-hydroxy-9-oxo-7-[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate

Synonym

2',7-di-TES-paclitaxel, (2'R,3'S)-2',7-(bis)triethylsilyl taxol; 2’,7-bis(triethylsilyl)Paclitaxel

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

T0120 Info Sheet PDF

References

Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.

Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.

Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.

Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.

Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.

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