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Ensartinib

Product ID E543721
Cas No. 1365267-27-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $133.50 In stock
25 mg $299.90 In stock
100 mg $1,022.10 In stock
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  • Product Info
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  • Description
  • Product Info
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  • Downloads
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Description

Ensartinib is a third-generation ALK inhibitor. In addition, ensartinib is found to also have activity against ROS1, MET, SLK, Axl, LTK, ABL and EPHA2.

Product Info

Cas No.

1365267-27-1

Purity

≥98%

Formula

C25H25Cl2FN6O3

Formula Wt.

547.41

Chemical Name

6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-N-[4-(4-methylpiperazine-1-carbonyl)phenyl]pyridazine-3-carboxamide

Synonym

X396, X-396

Solubility

DMSO:100 mg/mL (178.11 mM) Ethanol:100 mg/mL (178.11 mM) Water:Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E543721 MSDS PDF

Info Sheet

E543721 Info Sheet PDF

References

Horn L, Wakelee H, Reckamp KL, et al. MINI01.02: Response and plasma genotyping from phase I/II trial of ensartinib (X-396) in patients (pts) with ALK+ NSCLC: topic: medical oncology. J Thorac Oncol. 2016 Nov;11(11S)::S256-S257. PMID: 27969449

Caccese M, Ferrara R, Pilotto S, et al. Current and developing therapies for the treatment of non-small cell lung cancer with ALK abnormalities: update and perspectives for clinical practice. Expert Opin Pharmacother. 2016 Dec;17(17):2253-2266. PMID: 27682212

Dholaria B, Hammond W, Shreders A, et al. Emerging therapeutic agents for lung cancer. J Hematol Oncol. 2016 Dec 9;9(1):138. PMID: 27938382

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