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Corosolic Acid

Corosolic Acid

Product ID C5870
Cas No. 4547-24-4
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $193.90 In stock
25 mg $398.20 In stock
100 mg $1,225.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Corosolic acid is a pentacyclic triterpene extracted from the leaves of Lagerstroemia speciosa. Corosolic acid exhibits antioxidative, anti-diabetic, anti-atherosclerotic, and anticancer activities in vitro and in vivo. This compound decreases blood sugar and increases glucose uptake in vivo, and decreases overall cholesterol levels potentially through inhibition of cholesterol acyltransferase. In lung adenocarcinoma cells, corosolic acid increases reactive oxygen species and induces caspase-mediated apoptosis; it also inhibits activation of STAT3, NF-kB activity, and MCP-1.

Product Info

Cas No.

4547-24-4

Purity

≥98%

Formula

C30H48O4

Formula Wt.

472.70

IUPAC Name

(1S,2R,4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-1,2,6a,6b, 9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13, 14b-tetradecahydro-1H-picene-4a-carboxylic acid

Synonym

2α-Hydroxyursolic acid, Colosolic acid, Corsolic acid, Glucosol

Solubility

Soluble in DMSO.

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C5870 MSDS PDF

Info Sheet

C5870 Info Sheet PDF

References

Nho KJ, Chun JM, Kim HK. Corosolic acid induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro. Food Chem Toxicol. 2013 Jun;56:8-17. PMID: 23454206.

Horlad H, Fujiwara Y, Takemura K, et al. Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells. Mol Nutr Food Res. 2013 Jun;57(6):1046-54. PMID: 23417831.

Miura T, Takagi S, Ishida T. Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid. Evid Based Complement Alternat Med. 2012;2012:871495. PMID: 23082086.

Chen H, Yang J, Zhang Q, et al. Corosolic acid ameliorates atherosclerosis in apolipoprotein E-deficient mice by regulating the nuclear factor-κB signaling pathway and inhibiting monocyte chemoattractant protein-1 expression. Circ J. 2012;76(4):995-1003. PMID: 22293444.

Takagi S, Miura T, Ishihara E, et al. Effect of corosolic acid on dietary hypercholesterolemia and hepatic steatosis in KK-Ay diabetic mice. Biomed Res. 2010 Aug;31(4):213-8. PMID: 20834178.

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