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Isorhamnetin

Product ID I7357
Cas No. 480-19-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $83.40 In stock
5 mg $185.30 In stock
25 mg $555.70 In stock
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  • Description
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Description

Isorhamnetin is a flavonol found in Tagetes that exhibits anti-obesity, anti-inflammatory, antioxidative, anticancer chemotherapeutic, and chemopreventive activities. Isorhamnetin decreases levels of PPARγ, CEBPα, LXRα, and lipoprotein lipase in adipocytes. In animal models of edema, isorhamnetin decreases expression of COX-2 and production of ROS and increases expression of Nrf2 and heme oxygenase 1 (HO-1). In colon cancer cells, isorhamnetin inhibits cell proliferation, induces G2/M phase cell cycle arrest, increases expression of cyclin B1, and inhibits signaling of the PI3K/Akt/mTOR pathway. Additionally, this compound decreases tumor development induced by DSS and azoxymethane in vivo by inhibiting activity of Src and β-catenin.

Product Info

Cas No.

480-19-3

Purity

≥98%

Formula

C16H12O7

Formula Wt.

316.26

Chemical Name

3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone

IUPAC Name

3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)chromen-4-one

Synonym

3-Methylquercetin, Quercetin- 3'-methyl ether

Melting Point

305°C (dec.)

Solubility

Soluble in acetone, methanol, ethylacetate, DMSO or water.

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

I7357 MSDS PDF

Info Sheet

I7357 Info Sheet PDF

Brochures

WNT Booklet

References

Seo K, Yang JH, Kim SC, et al. The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1. Inflammation. 2014 Jun;37(3):712-22. PMID: 24337631.

Li C, Yang X, Chen C, et al. Isorhamnetin suppresses colon cancer cell growth through the PI3K Akt mTOR pathway. Mol Med Rep. 2014 Mar;9(3):935-40. PMID: 24398569.

Saud SM, Young MR, Jones-Hall YL, et al. Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-catenin. Cancer Res. 2013 Sep 1;73(17):5473-84. PMID: 23824743.

Kim JE, Lee DE, Lee KW, et al. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila). 2011 Apr;4(4):582-91. PMID: 21330379.

Lee J, Jung E, Lee J, et al. Isorhamnetin represses adipogenesis in 3T3-L1 cells. Obesity (Silver Spring). 2009 Feb;17(2):226-32. PMID: 18948972.

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