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Acitretin

Product ID A0933
Cas No. 55079-83-9
Purity ≥98%, multiple isomers
Product Unit SizeCostQuantityStock
25 mg $64.90 In stock
100 mg $138.90 In stock
250 mg $231.50 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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Description

Acitretin is an orally bioavailable retinoid that displays anti-inflammatory activity and is used clinically to treat psoriasis. Acitretin is a metabolite of etretinate that displays more optimized pharmacokinetic parameters. This compound activates all retinoic acid receptor subtypes (RARα/β/γ) without binding the receptor itself and also increases cAMP-PKA binding in erythrocytes.

Product Info

Cas No.

55079-83-9

Purity

≥98%, multiple isomers

Formula

C21H26O3

Formula Wt.

326.43

Chemical Name

9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

IUPAC Name

(2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4, 6,8-tetraenoic acid

Synonym

Neotigason, Soriatane

Appearance

Yellow to green-yellow crystalline powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A0933 MSDS PDF

Info Sheet

A0933 Info Sheet PDF

References

Niu X, Cao W, Ma H, et al. Acitretin exerted a greater influence on T-helper (Th)1 and Th17 than on Th2 cells in treatment of psoriasis vulgaris. J Dermatol. 2012 Nov;39(11):916-21. PMID: 22913391.

Saurat JH. Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment. J Am Acad Dermatol. 1999 Sep;41(3 Pt 2):S2-6. PMID: 10459139.

Raynaud F, Gerbaud P, Bouloc A, et al. Rapid effect of treatment of psoriatic erythrocytes with the synthetic retinoid acitretin to increase 8-azido cyclic AMP binding to the RI regulatory subunit. J Invest Dermatol. 1993 Jan;100(1):77-81. PMID: 8380830.

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