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Ginsenoside Rg2

Ginsenoside Rg2

Product ID G3459
Cas No. 52286-74-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $92.00 In stock
5 mg $306.20 In stock
10 mg $408.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ginsenoside Rg2 is a triterpene saponin originally found in species of Panax that exhibits anti-atherosclerotic, anti-diabetic, and neuroprotective activities. Ginsenoside Rg2 inhibits LPS-stimulated production of VCAM-1 and ICAM-1, prevents degradation of IκBα, and suppresses leukocyte adhesion in models of atherosclerosis. Ginsenoside Rg2 also decreases production of PEPCK and G6Pase and phosphorylates AMPK and GSK-3β, suppressing hepatic glucose production in vitro. Additionally, this compound decreases expression of Bcl-2 and HSP70 and increases expression of Bax and p53, improving neural performance and cognition in animal models of vascular dementia.

Product Info

Cas No.

52286-74-5

Purity

≥98%

Formula

C42H72O13

Formula Wt.

785.01

IUPAC Name

(2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-2-[[(6R,10R,12S,14R)-3, 12-dihydroxy-17-[(E,2S)-2-hydroxy-6-methyloct-5-en-2-yl]-4,4,10, 14-tetramethyl-1,2,3,5,6,7,8,9,11,12,13,15,16, 17-tetradecahydrocyclopenta[a]phenanthren-6-yl]oxy]-4, 5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol

Appearance

White powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

G3459 MSDS PDF

Info Sheet

G3459 Info Sheet PDF

References

Cho YS, Kim CH, Ha TS, et al. Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Korean J Physiol Pharmacol. 2013 Apr;17(2):133-7. PMID: 23626475.

Yuan HD, Kim do Y, Quan HY, et al. Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells. Chem Biol Interact. 2012 Jan 5;195(1):35-42. PMID: 22062806.

Zhang G, Liu A, Zhou Y, et al. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. J Ethnopharmacol. 2008 Feb 12;115(3):441-8. PMID: 18083315.

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