LY364947 is an inhibitor of activin receptor-like kinase 5 (ALK5), a type of TGF-β1 receptor. LY364947 displays anticancer and anti-fibrotic activities. LY364947 improves the radiosensitivity of non-small cell lung cancer (NSCLC) cells. In animal models of liver damage, this compound enhances liver regeneration, cell proliferation, and liver function.
| Cas No. | 396129-53-6 |
|---|---|
| Purity | ≥98% |
| Formula | C17H12N4 |
| Formula Wt. | 272.31 |
| IUPAC Name | 4-[3-(2-Pyridinyl)-1H-pyrazol-4-yl]quinoline |
| Synonym | LY364947 |
| Solubility | DMSO 1 mg/mL (3.67 mM) Water Insoluble Ethanol Insoluble |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Du S, Bouquet S, Lo CH, et al. Attenuation of the DNA damage response by transforming growth factor-beta inhibitors enhances radiation sensitivity of non-small-cell lung cancer cells in vitro and in vivo. Int J Radiat Oncol Biol Phys. 2015 Jan 1;91(1):91-9. PMID: 25835621.
Karkampouna S, Goumans MJ, Ten Dijke P, et al. Inhibition of TGFβ type I receptor activity facilitates liver regeneration upon acute CCl4 intoxication in mice. Arch Toxicol. 2015 Jan 8. [Epub ahead of print]. PMID: 25566828.
