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XAV-939

Product ID X0384
Cas No. 284028-89-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $64.30 In stock
25 mg $263.30 In stock
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  • Description
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Description

XAV-939 inhibits tankyrases and wnt pathway signaling. XAV exhibits anti-fibrotic activity and shows potential anticancer chemotherapeutic benefit when co-administered with other compounds. XAV-939 decreases nuclear accumulation of β-catenin and decreases c-myc levels, decreasing bleomycin-induced dermal thickening. In both in vitro and in vivo models of cancer, this compound reverses resistance to PI3K and Akt inhibitors.

Product Info

Cas No.

284028-89-3

Purity

≥98%

Formula

C14H11F3N2OS

Formula Wt.

312.31

Chemical Name

2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol

IUPAC Name

2-[4-(Trifluoromethyl)phenyl]-1,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one

Solubility

DMSO (25mg/ml)

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

X0384 MSDS PDF

Info Sheet

X0384 Info Sheet PDF

References

Bilir B, Kucuk O, Moreno CS. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013 Nov 4;11(1):280. [Epub ahead of print]. PMID: 24188694

Distler A, Deloch L, Huang J, et al. Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling. Ann Rheum Dis. 2013 Sep 1;72(9):1575-80. PMID: 23148305.

Tenbaum SP, Ordóñez-Morán P, Puig I, et al. β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med. 2012 Jun;18(6):892-901. PMID: 22610277.

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